中老年人维生素D水平对骨质疏松的影响及相关性分析  

The Effects of the Vitamin D Level on Osteoporosis in the Middle-Aged and the Elderly: a Correlation Study

作　　者：滑丽美[1] 薛苏娟[2] 曹婧然[3] 李绍建 雷敏[2] 于建敏[4] HUA Li-mei;XUE Su-juan;CAO Jing-ran;LI Shao-jian;LEI Min;YU Jian-min(Department of Nutrition, Bethune International Peace Hospital of PLA, Shijiazhuang 050082, China;Department of Nutrition, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China;Department of Nutrition, the Second Hospital of Tianjin Medical University, Tianjin 300211, China;Department of Out-patient, 309 Hospital of PLA, Beijing 100091, China)

机构地区：[1]解放军白求恩国际和平医院营养科,石家庄050082 [2]河北医科大学第三医院营养科,石家庄050051 [3]天津医科大学第二医院营养科,天津300211 [4]解放军309医院门诊部,北京100091

出　　处：《临床误诊误治》2018年第12期76-79,共4页Clinical Misdiagnosis & Mistherapy

基　　金：河北省卫健委指导性计划课题(20150387)

摘　　要：目的探讨中老年人维生素D水平对骨质疏松的影响及其相关性。方法选取2012年1月—12月行体检的中老年人80例,均行不同部位骨密度测定及维生素D水平检测。按照骨密度不同,分为骨质疏松组、骨量减少组及骨量正常组,而骨量减少组与骨量正常组又统称为非骨质疏松组。比较不同部位骨密度及维生素D表达水平,采用logistic分析探究维生素D与骨质疏松的相关性。结果本研究骨质疏松组19例,骨量减少组27例,骨量正常组34例。与骨质疏松组比较,骨量减少组、骨量正常组的腰2～腰3、股骨颈、大粗隆及Wards三角的骨密度升高,差异有统计学意义(P <0. 05)。骨质疏松组、骨量减少组、骨量正常组25羟维生素D水平分别为(53. 13±11. 71) mmol/L、(57. 24±12. 73) mmol/L、(57. 82±13. 53) mmol/L,比较差异无统计学意义(P> 0. 05)。骨质疏松组与非骨质疏松组性别、年龄、25羟维生素D及碱性磷酸酶水平比较差异有统计学意义(P <0. 05)。logistic回归分析显示,25羟维生素D及碱性磷酸酶水平、年龄与性别为骨质疏松的高危因素。结论临床可通过骨密度测定及时诊断骨质疏松,而骨密度降低与维生素D缺乏、年龄、碱性磷酸酶降低有关。Objective To probe the effects of the vitamin D level on osteoporosis in the elderly and their correlation.Methods Eighty-eight middle-aged and elderly people who underwent physical examination in our hospital from January to December2012were selected for bone mineral density(BMD)measurement and vitamin D level testing in different parts of body.According to different levels of BMD,all these patients were divided into osteoporosis group,osteopenia group and normal BMD group.The osteopenia group and normal BMD group were collectively called non-osteoporosis group.The expression levels of vitamin D and BMD at different parts of body were compared and the correlation between vitamin D and osteoporosis were researched with logistic analysis.Results In this study,there were19patients in osteoporosis group,27in osteopenia group and34in normal BMD group.Compared with the osteoporosis group,BMD of L2-3,femoral neck,large trochanter and Wards triangle was increased in osteopenia group and normal BMD group,and the difference was statistically significant(P<0.05).The levels of25-hydroxyvitamin D in the osteoporosis group,the osteopenia group and the normal BMD group were(53.13±11.71)mmol/L,(57.24±12.73)mmol/L,and(57.82±13.53)mmol/L,respectively.There was no statistically significant difference(P>0.05).Significant differences were found in sex,age,25-hydroxyvitamin D and alkaline phosphatase levels between the osteoporosis group and non-osteoporosis group(P<0.05).Logistic regression analysis showed that25-hydroxyvitamin D,alkaline phosphatase(ALP)levels,age and gender were risk factors for osteoporosis.Conclusion Osteoporosis can be diagnosed in time by BMD measurement,and BMD reduction is associated with vitamin D deficiency,age,and ALP reduction.

关 键 词：骨质疏松 老年人 维生素D 骨密度 

分 类 号：R681[医药卫生—骨科学]