左氧氟沙星联合盐酸氨溴索对老年重症肺炎患者免疫功能、肺功能和血气指标的影响  

Effects of levofloxacin combined with ambroxol hydrochloride on immune function,lung function and blood gas index in elderly patients with severe pneumonia

作　　者：高光霞 唐兵[1] GAO Guang-xia;TANG Bing(Department of ICU,The Sixth Peoples Hospital of Chengdu,Chengdu 610051, China)

机构地区：[1]成都市第六人民医院ICU,四川成都610051

出　　处：《吉林医学》2018年第12期2224-2226,共3页Jilin Medical Journal

摘　　要：目的:研究对老年重症肺炎患者应用左氧氟沙星联合盐酸氨溴索对其免疫功能、肺功能及血气指标的影响及临床效果。方法:选择呼吸科重症肺炎患者100例随机分为观察组与对照组。对照组50例,在对症支持治疗基础上,予以左氧氟沙星口服;观察组50例,加用盐酸氨溴索。比较两组临床表现差异。结果:治疗前,指标无显著差异(P> 0. 05);治疗后,两组患者较治疗前CD_3^+、、CD_4^+及CD_4^+/CD_8^+均具有显著变化,其中观察组治疗后CD_3^+为(67. 78±7. 22)、CD_4^+为(39. 97±3. 13)及CD_4^+/CD_8^+为(2. 36±0. 37),均优于对照组,差异有统计学意义(P <0. 05); CD_8^+指标两组患者治疗前后比较,差异无统计学意义(P> 0. 05)。治疗前,肺功能指标比较,差异无统计学意义(P> 0. 05);治疗后,两组患者较治疗前获得显著改善,差异有统计学意义(P <0. 05),其中观察组FEV1为(2. 81±0. 33) L、FVC为(3. 93±0. 52) L、PEF为(3. 77±0. 51) L/s、MMEF为(0. 97±0. 45) L/s,优于对照组,差异有统计学意义(P <0. 05)。治疗前,血气指标比较,差异无统计学意义(P> 0. 05);治疗后,两组患者各项指标均显著高于治疗前,差异有统计学意义(P <0. 05);其中观察组PaO_2为(97. 22±8. 22) mm Hg、Pa CO2为(30. 97±3. 13) mm Hg、SoO_2为(96. 22±7. 95)%、SoO_2/FiO_2为(332. 36±9. 37) mm Hg,均显著高于对照组,差异有统计学意义(P <0. 05)。结论:对老年重症肺炎患者联合左氧氟沙星与盐酸氨溴索一方面能够发挥较强的抗菌杀菌作用;同时还可改善肺部顺应性促进痰液排出,进一步改善机体免疫力并促进疾病恢复,对提高免疫功能,改善呼吸情况及增加血氧水平均具有较好的临床效果。Objective To discuss the effect and clinical effect of combination of levofloxacin and ambroxol on immune function,pulmonary function and blood gas index in elderly patients with severe pneumonia. Method 100 cases of severe pneumonia in Department of respiration in our hospital were randomly divided into the observation group and the control group. In the control group,50 cases were taken orally with levofloxacin on the basis of symptomatic support treatment,and 50 cases in the observation group were added with ambroxol hydrochloric acid on the basis of the above. The lung function index,blood gas index and immune cell index were compared between the two groups after different drug treatment. Results Before treatment,there was no significant difference between the index( P > 0. 05); after treatment,two groups of patients before treatment,CD3+,CD4+ and CD4+/CD8+ were significant changes in the observation group after treatment for CD3+( 67. 78 ± 7. 22),and CD4+( 39. 97 ± 3. 13) and CD4+/CD8+( 2. 36 ± 0. 37),all better than the control group( P < 0. 05); CD8+ index before and after treatment in two groups showed no significant difference( P > 0. 05). Before treatment,no significant differences in lung function index( P > 0. 05); after treatment,compared with patients in two groups before treatment significantly improved( P < 0. 05),the observation group FEV1( 2. 81 ±0. 33) L,FVC( 3. 93 ± 0. 52) L,PEF( 3. 77 ± 0. 51) L/s,MMEF for( 0. 97 ± 0. 45) L/s,better than the control group( P <0. 05). Before treatment,no significant differences in blood gas index( P > 0. 05); after treatment,two groups were significantly higher than those before treatment( P < 0. 05); the observation group PaO2( 97. 22 ± 8. 22) mm Hg,Pa CO2( 30. 97 ± 3. 13) mmHg,SoO2( 96. 22 ± 7. 95) %,SoO2/FiO2 for( 332. 36 ± 9. 37) mm Hg,were significantly higher than control group( P < 0. 05). Conclusion To exert their antibacterial strong bactericidal effect to elderly patients with severe pneumonia combined with levofloxacin and ambroxol hydroc

关 键 词：左氧氟沙星 盐酸氨溴索 老年重症肺炎 免疫功能 肺功能 血气指标 

分 类 号：R563.1[医药卫生—呼吸系统]