皮层肌动蛋白结合蛋白Cortactin研究进展  

Progress in research on Cortactin

作　　者：林宇斌 仲艾芳 刘胜华[2] 陈微微[2] 曾广会 温建立[2] LIN Yu-bin;ZH0NG AI-fang;LIU Sheng-hua(Zunyi Medical College,Zunyi 553000,China;The Third Affiliated Hospital of Zunyi Medical College,Zunyi 553000,China)

机构地区：[1]遵义医学院,贵州遵义563000 [2]遵义医学院第三附属医院,贵州遵义563000

出　　处：《吉林医学》2018年第12期2367-2371,共5页Jilin Medical Journal

基　　金：贵州省科技厅科学技术基金项目(项目编号:黔科合J字[2014]2173号)

摘　　要：皮层肌动蛋白结合蛋白Cortactin参与细胞的多种细胞活动,其中包括细胞的板状伪足突起形成、突触形成、囊泡运输、胞吐、胞吞、细胞间黏附、侵袭性、细胞迁移、运动以及细胞分裂等作用,上诉细胞过程都是通过调控各微丝的聚合而发挥相应作用,Cortactin在皮层微丝肌动蛋白的组装上发挥着不可替代的作用。Cortactin是酪氨酸激酶Scr主要底物,酪氨酸磷酸化对Cortactin功能起调节作用。Cortactin在细胞活动中的作用,表明Cortactin不仅在癌细胞运动及侵袭上发挥重要作用,在炎性反应及人体气道分泌和收缩机制上也有着重要作用。所以对Cortactin在微丝肌动蛋白的组装及磷酸化等的研究,将阐明Cortactin具体作用的机制。Cortactin is involved in a variety of cellular activities in cells,such as formation of invadopodia,synapse formation,vesicle transportation,Exocytosis,endocytosis,intercellular cohesion,invasiveness,cell migration and cell division,all those cell processes play a role by regulating the aggregation of microfilaments,cortactin plays an irreplaceable role in the assembly of cortical microfilament actin. Cortactin is the major substrate for tyrosine kinase Scr,and tyrosine phosphorylation regulates the function of Cortactin. The role of Cortactin in cell activities suggests that Cortactin not only plays an important role in cancer cell movement and invasion,but also plays an important role in inflammation and secretion and contraction of human airways. Therefore,the study of the assembly and phosphorylation of Cortactin in microfilament actin will elucidate the mechanism of the specific action of Cortactin.

关 键 词：皮层肌动蛋白结合蛋白 微丝相关蛋白2/3复合物 磷酸化 板状伪足突起 

分 类 号：R341[医药卫生—基础医学]