支气管哮喘合并感染性肺炎患儿对血小板指标、炎性因子水平及Th1/Th2比值的影响分析  

Effect of Inflammatory Factors and Th1/Th2 Ratio on Platelet Index in Children with Bronchial Asthma Complicated with Infectious Pneumonia

作　　者：王雪玉[1] 姚静桦 WANG Xueyu;YAO Jinghua(Jianyang People’s Hospital,Jianyang 641400,China)

机构地区：[1]简阳市人民医院,四川简阳641400

出　　处：《中外医学研究》2018年第34期3-5,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析支气管哮喘合并感染性肺炎患儿对血小板指标、炎性因子水平及Th1/Th2比值的影响。方法:随机选择2017年6月-2018年6月在笔者所在医院儿科进行治疗的支气管哮喘患儿、感染性肺炎患儿、支气管哮喘合并感染性肺炎患儿各50例进行临床研究。比较三组患者PLT、PDW、MPV等血小板相关指标,三组患者TNF-α、IL-6、IL-12炎症因子水平,以及三组患者Th1、Th2水平和Th1/Th2。结果:三组患者PLT、PDW、MPV水平比较,差异有统计学意义(P<0.05);支气管哮喘+感染性肺炎组患者PLT、PDW明显高于支气管哮喘组和感染性肺炎组,MPV低于支气管哮喘组和感染性肺炎组(P<0.05)。三组患者TNF-α、IL-6、IL-12水平比较,差异有统计学意义(P<0.05);支气管哮喘+感染性肺炎组患者TNF-α、IL-6明显高于支气管哮喘组和感染性肺炎组,IL-12低于支气管哮喘组和感染性肺炎组(P<0.05)。三组患者Th1、Th2、Th1/Th2水平比较差异有统计学意义(P<0.05);支气管哮喘+感染性肺炎组Th1、Th1/Th2水平低于支气管哮喘组、感染性肺炎组,Th2高于其余两组(P<0.05)。结论:支气管哮喘合并感染性肺炎患者的血小板指标、炎性因子水平、Th1/Th2水平与支气管哮喘和感染性肺炎患儿均有明显差异,能够为患儿的诊断提供依据。Objective:To analyze the effects of bronchial asthma with infectious pneumonia on platelet index,inflammatory factors and Th1/Th2 ratio.Method:A total of 50 children with bronchial asthma,50 children with infectious pneumonia and 50 children with bronchial asthma complicated with infectious pneumonia were randomly selected from June 2017 to June 2018. Related indexes such as PLT,PDW and MPV platelet were compared among the three groups.The levels of TNF-a,IL-6 and IL-12 inflammatory factors were compared among the three groups.The levels of Th1,Th2 and Th1/Th2 were compared among the three groups.Result:The levels of PLT,PDW and MPV in the three groups were significantly different(P<0.05).The levels of PLT and PDW in the bronchial asthma and infectious pneumonia group were significantly higher than those in the bronchial asthma group and infectious pneumonia group,and MPV was lower than those in the bronchial asthma group and infectious pneumonia group(P<0.05).The levels of TNF-a,IL-6 and IL-12 in the three groups were significantly different(P<0.05).The levels of TNF-a and IL-6 in bronchial asthma and infectious pneumonia group were significantly higher than those in the patients bronchial asthma group and infectious pneumonia group,and the levels of IL-12 were significantly lower than those in the bronchial asthma group and infectious pneumonia group(P<0.05).The levels of Th1, Th2 and Th1/Th2 in the three groups were significantly different(P<0.05).The levels of Th1 and Th1/Th2 in the bronchial asthma and infectious pneumonia group were lower than those in the bronchial asthma group and the infectious pneumonia group,and the levels of Th2 were higher than those in the other two groups(P<0.05).Conclusion:The levels of platelet markers,inflammatory factors and Th1/Th2 in patients with bronchial asthma complicated with infectious pneumonia are significantly different from those in children with bronchial asthma and infectious pneumonia.

关 键 词：支气管哮喘 感染性肺炎 血小板 炎性因子 TH1/TH2 

分 类 号：R725.6[医药卫生—儿科]