ALDH2Glu487Lys多态性与饮酒、阻塞性睡眠呼吸暂停低通气综合征的相关性分析  

ALDH2 Gene Polymorphism,Alcohol Consumption and Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：翁婷[1] 高蔚[1] 王丽芳[1] 金亮 吴颖 王小雨[1] 施斌[1] 费力娟 WENG Ting;GAO Wei;WANG Lifang;JIN Liang;WU Ying;WANG Xiaoyu;SHI Bin;FEI Lijuan(Department of Respiratory Medicine, Suqian People’s Hospital of Nanjing Drum Tower Hospital Group, Suqian Jiangsu 223800, China)

机构地区：[1]南京鼓楼医院集团宿迁市人民医院呼吸科,江苏宿迁223800

出　　处：《中国继续医学教育》2018年第35期99-102,共4页China Continuing Medical Education

基　　金：宿迁市科技支撑计划项目(S201518)

摘　　要：目的探讨有打鼾史的男性患者乙醛脱氢酶2(ALDH2)Glu487基因多态性与饮酒行为、阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的关系。方法以321例打鼾男性作为研究对象。采用多导睡眠呼吸监测,将其分为OSAHS组208例和113例对照组(非OSAHS)。调查入组者的饮酒史,计算每日、每月及累积饮酒量,分析ALDH2 Glu487Lys基因多态性与酒精摄入量及OSAHS发病的相关性。结果 OSAHS组饮酒率较对照组高,差别无统计学意义(P> 0.05);OSAHS组与对照组的ALDH2Glu487Lys位点的等位基因频率分布比较,差异无统计学意义(P>0.05);野生基因型携带者(G/G)的平均饮酒量及累积饮酒量明显增加,差异具有统计学意义(P <0.05);与携带ALDH2(G/G)基因型者相比,其它基因型OSAHS的发生率无增加,差异无统计学意义(P> 0.05)。结论 ALDH2 Glu487Lys位点的基因多态性与患者饮酒量有相关性,携带G/G基因型饮酒量增加,ALDH2 Glu487Lys基因多态性与OSAHS易感性无相关。Objective To evaluate the relationship among ALDH2gene polymorphism,and chronic alcohol ingestion,obstructive sleep apnea hypopnea syndrome(OSAHS).Methods321patients with snoring were studied,all patients underwent overnight sleep monitoring,and there were OSAHS group(208cases)and non-OSAHS group(113cases)according to the apnea-hypopnea index(AHI).To investigate the drinking history of all subjects,the relationship between gene polymorphism and alcohol consumption were analyzed;the relationship between gene polymorphism and OSAHS were analyzed.Results The drinking rate of OSAHS group was higher than that of control group,with no significant difference(P>0.05).There was no significant difference in allele frequency distribution of ALDH2Glu487Lys locus between OSAHS group and control group(P>0.05).The average and cumulative alcohol consumption of wild genotype carriers(G/G)increased significantly(P<0.05).Compared with those with ALDH2(G/G)genotype,the incidence of OSAHS of other genotypes did not increase,and there was no significant difference(P>0.05).Conclusion ALDH2Glu487Lys genetic polymorphism was associated with alcohol consumption in male drinkers,but not related to the development of OSAHS.

关 键 词：饮酒 累积饮酒量 多导睡眠呼吸监测 阻塞性睡眠呼吸暂停低通气综合征 基因多态性 乙醛脱氢酶2Glu487Lys 

分 类 号：R766[医药卫生—耳鼻咽喉科]