消癌平注射液改善骨髓增生异常综合征模型动物骨髓病态造血研究  

Effects of xiaoaiping injection on dyshaematopoiesis in the model animals with myelodysplastic syndrome

作　　者：黄晓[1] 张晓波 宋延平[3] 祁宇[1] 张雅月[1] 王冲[1] 孙丽丽 马薇[1] HUANG Xiao;ZHANG Xiao-bo;SONG Yan-ping;QI Yu;ZHANG Ya-yue;WANG Chong;SUN Li-li;MA Wei(Dongzhimen Hospital Affiliated to Beijing University of Traditional Chinese Medicine,Beijing100700;Central Hospital of Genghis Khan Tou Zhalantun City Inner Mongolia,Hulunbuir Mongolia021000;Pharmacology Laboratory,Shaanxi Academy of Traditional Chinese Medicine,Xiran Shaanxi710003)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]内蒙古呼伦贝尔市扎兰屯市成吉思汗镇中心卫生院,内蒙古呼伦贝尔021000 [3]陕西省中医药研究院药理实验室,陕西西安710003

出　　处：《世界中西医结合杂志》2018年第11期1540-1543,共4页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察消癌平注射液对骨髓增生异常综合征模型动物外周血象、骨髓象以及骨髓病态造血的影响。方法采用诱变剂DMBA复制骨髓增生异常综合征大鼠模型。观察消癌平注射液对MDS造模大鼠外周血象、骨髓增生程度以及骨髓病态造血的影响。结果模型组WBC、RBC、HGB和PLT与空白对照组比较明显降低(P <0. 01)。消癌平大、中剂量组WBC与模型组比较明显升高(P <0. 01,P <0. 05),维甲酸组、益血生组、消癌平大、中剂量组RBC与模型组比较明显升高(P <0. 01,P <0. 05),维甲酸组、消癌平大、中剂量组HGB与模型组比较明显升高(P <0. 01,P <0. 05),益血生组、消癌平大、中剂量组PLT与模型组比较明显升高(P <0. 01,P <0. 05)。模型组与空白对照组比较,胸腺指数和脾脏指数明显降低(P <0. 05),益血生组胸腺指数与模型组比较明显降低(P <0. 01),维甲酸组、消癌平大、中剂量组脾脏指数与模型组比较明显升高(P <0. 05)。模型组骨髓增生程度评分与空白对照组比较明显升高(P <0. 01),维甲酸组、消癌平大、中剂量组骨髓增生程度评分与模型组比较明显降低(P <0. 01,P <0. 05)。模型组骨髓病态造血评分与空白对照组比较明显升高(P <0. 01),益血生组、维甲酸组、消癌平大剂量组骨髓病态造血评分与模型组比较明显降低(P <0. 01,P <0. 05)。结论消癌平注射液对MDS模型大鼠外周血象降低有提升效果,能调节骨髓增生状态与改善骨髓病态造血,并能增加脾脏指数。Objective To observe the effects of xiaoaiping injection on peripheral hemogram,myelogram and dyshaematopoiesis of the model animals with myelodysplastic syndrome.Methods The mutagenic agent DMBA was used to duplicate the model rats with myelodysplastic syndrome.The effects of xiaoaiping injection on peripheral hemogram,bone marrow hyperplasia and bone marrow dyshaematopoiesis were observed in MDS rat models.Results Compared with the blank control group,the results of WBC,RBC,HGB and PLT were all lower obviously in the model groups(P<0.01).Compared with the model group,WBC in the large-dose and middle-dose groups of xiaoaiping were increased obviously(P<0.01,P<0.05),RBC in the tretinoin group,yixuesheng group and the large-dose and middle-dose groups of xiaoaiping were all increased obviously(P<0.01,P<0.05),HGB in the tretinoin group and the large-dose and middle-dose groups of xiaoaiping were all increased obviously(P<0.01,P<0.05).PLT in the yixuesheng group and the large-dose and middle-dose groups of xiaoaiping were all increased obviously(P<0.01,P<0.05).The thymus index and the spleen index were reduced obviously in the model group as compared with the blank control group(P<0.05),the thymus index in the yixuesheng group was reduced obviously as compared with model group(P<0.01)and the spleen index in the tretinoin group and the large-dose and middle-dose groups of xiaoaiping were increased obviously as compared with the model group(P<0.05).The score of bone marrow hyperplasia in the model group was increased obviously as compared with the blank control group(P<0.01)and the scores of it in the tretinoin group and the large-dose and middle-dose groups of xiaoaiping were reduced obviously as compared with the model group(P<0.01,P<0.05).The score of bone marrow dyshaematopoiesis in the model group was increased obviously as compared with the blank control group(P<0.01)and the scores of it in the yixuesheng group,the tretinoin group and the large-dose group of xiaoaiping were all lower obviously as compared with t

关 键 词：消癌平注射液 骨髓增生异常综合征 病态造血 

分 类 号：R285[医药卫生—中药学]