外周血白细胞计数与妊娠期糖尿病的相关性  

Correlation between peripheral blood leukocyte count and gestational diabetes mellitus

作　　者：华素环 李筱梅[1] 乔小改[1] 王冬亮[1] Hua Suhuan;Li Xiaomei;Qiao Xiaogai;Wang Dongliang(The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450014, China)

机构地区：[1]郑州大学第二附属医院,河南郑州450014

出　　处：《当代医学》2018年第35期26-29,共4页Contemporary Medicine

摘　　要：目的探讨白细胞计数及中性粒细胞与妊娠期糖尿病(GDM)的相关性。方法回顾性选取郑州大学第二附属医院2017年1月至2018年1月期间孕周为37～42周定期行围产保健的316例单胎初产孕妇,将其分为妊娠期糖尿病组(GDM组)158例和正常妊娠组(即对照组)158例。比较两组孕妇中的白细胞计数(WBC×10~9)及中性粒细胞百分比(NEUT%)情况,并对WBC(×10~9)及NEUT(%)进行预测GDM患病的ROC曲线对比分析,探讨妊娠期WBC(×10~9)及NEUT(%)变化情况与GDM发生的相关性。结果对两组孕妇中WBC(×10~9)及NEUT(%)值进行比较得出,GDM组孕妇WBC(×10~9)及NEUT(%)值高于对照组,且WBC(×10~9)及NEUT(%)预测GDM患病的ROC曲线面积为0.677、0.589,均具有统计学意义(P<0.05),而GDM与WBC(×10~9)的相关系数为0.307,呈正相关,GDM与NEUT(%)相关系数为0.153,但因其相关系数<0.3,认为GDM与NEUT(%)无明显相关性。结论 WBC(×10~9)可以作为一项常用检测指标,评估孕妇罹患GDM的风险性,为及早发现围产保健孕妇GDM的发生提供一定参考。Objective To explore the correlation between white blood cell count and neutrophils and gestational diabetes mellitus(GDM).Methods A retrospective study was made to select316single pregnant women with single pregnancy for37-42weeks of perinatal health care in the Second Affiliated Hospital of Zhengzhou University,January2017to January2018,which were divided into158cases of gestational diabetes group(group GDM)and158cases of normal pregnancy group(the control group).The white blood cell count(WBC×10^9)and the percentage of neutrophils(NEUT%)were compared in the two groups of pregnant women,and the ROC curve of GDM prevalence was predicted by WBC(×10^9)and NEUT(%),and the changes of WBC(×10^9)and NEUT(%)in pregnancy were discussed and the correlation between the occurrence of GDM and the occurrence of GDM.Results The values of WBC(×10^9)and NEUT(%)in the two groups of pregnant women were compared.The values of WBC(×10^9)and NEUT(%)in group GDM were higher than those of the control group.The ROC curve area of WBC(×10^9)and NEUT(%)predicted GDM prevalence was0.677and0.589,which were all statistically significant(P<0.05).The correlation coefficient between GDM and WBC(×10^9)was0.307,showing a positive correlation.The correlation coefficient between GDM and NEUT(%)was0.153,but the correlation coefficient was less than0.3.There was no significant correlation between GDM and NEUT(%).Conclusion WBC(×10^9)can be used as a common detection index to assess the risk of pregnant women with GDM and provide a reference for the early detection of GDM in perinatal pregnant women.

关 键 词：妊娠期糖尿病(GDM) 白细胞(WBC) 中性粒细胞(NEUT) 

分 类 号：R714.256[医药卫生—妇产科学]