创伤早期血清炎性标志物不同阶段的表达及意义  

Expression and significance of serum inflammatory markers at different stages of early trauma

作　　者：林兆恒 Lin Zhaoheng(Intensive Care Unit,the People's Hospital of Xishuangbanna Dai Autonomous Prefecture 666100)

机构地区：[1]西双版纳傣族自治州人民医院重症医学科,666100

出　　处：《中国社区医师》2018年第34期138-138,141,共2页Chinese Community Doctors

摘　　要：目的:探讨创伤早期血清炎性标志物不同阶段的表达及意义。方法:收治机械性创伤患者119例,随机分为试验组和对照组。试验组接受TNF-α和PCT检测,对照组接受C反应蛋白、白细胞计数、中性粒细胞计数检测,所有患者均接受急性生理和慢性健康状态评价评分(APACHEⅡ)。结果:在创伤早期,试验组有29例(74.35%)的TNF-α和PCT检测值达峰时与未发生MODS的患者比较差异有统计学意义;对照组有8例患者的各项指标达峰时与未发生MODS的患者比较差异有统计学意义,两组差异有统计学意义(P<0.01);APACHEⅡ的演变趋势与MODS没有正相关。结论:在机械性创伤发生的早期,可以利用TNF-α和PCT来预测MODS的发生。Objective:To explore the expression and significance of serum inflammatory markers at different stages of early trauma.Methods:119 patients with mechanical trauma were selected,they were randomly divided into the experimental group and the control group,the experimental group received TNF-alpha and PCT detection,the control group received C reactive protein,white blood cell count and neutrophil count detection,all patients received acute physiology and chronic health assessment score(APACHEⅡ).Results:In the early stage of trauma,there were 29 cases(74.35%)in the experimental group whose TNF-alpha and PCT values reached the peak,which was significantly different from those in the patients without MODS.In the control group,there was a significant difference in peak time of each indexes between 8 patients with patients without MODS,the difference between the two groups was statistically significant(P<0.01).There was no positive correlation between the evolution trend of APACHEⅡand MODS.Conclusion:In the early stage of mechanical trauma,TNF-alpha and PCT can be used to predict the occurrence of MODS.

关 键 词：创伤早期 血清标记物 表达 

分 类 号：R641[医药卫生—外科学]