侵袭性肺曲霉病手术切除术后联合伏立康唑治疗效果分析  

Effect of Combination of Voriconazole with Surgical Resection of Invasive Pulmonary Aspergillosis

作　　者：余忠技 金婧茹 YU Zhong-ji;JIN Jing-ru(Department of Respiratory, Shangrao People's Hospital, Shangrao Jiangxi 334000, China)

机构地区：[1]上饶市人民医院呼吸科,江西上饶334000

出　　处：《药品评价》2018年第24期15-17,共3页Drug Evaluation

摘　　要：目的:分析侵袭性肺曲霉病手术切除术后联合伏立康唑治疗的效果及预后影响。方法:选取2014年1月—2018年1月本院胸外科手术切除的侵袭性肺曲霉病患者12例为本次研究对象,根据术后治疗方法不同将患者分为两组,观察组术后给予伏立康唑治疗,对照组术后给予相同计量的安慰剂口服,观察两组治疗效果。结果:观察组的治疗效果明显高于对照组,差异有统计学意义(P<0.05)。而血清学检测结果表明,对照组有2人在术后6个月出现血清半乳甘露聚糖(Galactomannan,GM)异常升高,观察组血清GM明显低于对照组,差异有统计学意义(P<0.05)。结论:侵袭性肺曲霉病手术切除术后辅以伏立康唑治疗,治疗效果明显。Objective:To analyze the effect and prognosis of combined voriconazole with surgical resection of invasive pulmonary aspergillosis.Methods:A total of12patients with invasive pulmonary aspergillosis who underwent thoracic surgery in our hospital from January2014to February2018were enrolled.The patients were divided into two groups according to the different treatment methods.The patients in the control group were given the same dose of placebo after the treatment with voriconazole,and the effects of the two groups were observed.Results:The therapeutic effect of the observation group was significantly higher than that of the control group(P<0.05).Serological tests showed that6months after operation,2patients in the control group had abnormal GM elevation at6months after operation.The serum GM in the observation group was significantly lower than that in the control group(P<0.05).Conclusions:The study shows that treatment with voriconazole is effective,and it is worthy of promotion in clinical application.

关 键 词：侵袭性肺曲霉病手术切除术 伏立康唑 预后 

分 类 号：R982[医药卫生—药品]