治疗重症低血压新药——血管紧张素Ⅱ  

A new drug of treating severe hypotension: angiotensin Ⅱ

作　　者：李艳娇[1] 董雷[1] 韩腾飞 陶娌娜[1] LI Yan-jiao;DONG Lei;HAN Teng-fei;TAO Li-na(Department of Pharmacy,the First Hospital of Jilin University,Changchun 130021,China;College of Pharmacy,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院药学部,长春130021 [2]吉林大学药学院,长春130021

出　　处：《实用药物与临床》2018年第12期1430-1433,共4页Practical Pharmacy and Clinical Remedies

摘　　要：休克是组织灌流不足引起的代谢和细胞受损的病理过程,与低血压相关。血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)是一种有效的血管升压药,可以升高成人脓毒性或其他分布性休克患者的血压。本文从AngⅡ的作用机制和药物结构、药动学、临床研究、用法用量、药物相互作用、药物安全性及不良反应等方面进行综述。Shock is a pathological process of metabolism and cellular damage caused by inadequate perfusion of tissue,which is always associated with hypotension.AngiotensinⅡis a potent vasopressor,which can increase blood pressure in patients with sepsis or other septic shock in adults.This article reviews its mechanism of action and drug structure,pharmacokinetics,clinical research,usage and dosage,drug interactions,drug safety and adverse reactions,etc.

关 键 词：血管紧张素Ⅱ 脓毒性休克 分布性休克 低血压 

分 类 号：R972[医药卫生—药品]