慢性阻塞性肺疾病患者血清可溶性人基质裂解素2的表达水平及其临床意义  

Expression level and its clinical significance of serum soluble suppression of tumorigenicity 2 in patients with chronic obstructive pulmonary disease

作　　者：农正道 施维[1] 邓嘉宁[1] 邝敏[1] NONG Zheng-dao;SHI Wei;DENG Jia-ning;KUANG Min(Department of Respiratory Medicine,the Second People's Hospital of Nanning,530031,China)

机构地区：[1]广西南宁市第二人民医院呼吸内科,南宁市530031

出　　处：《广西医学》2018年第22期2672-2674,共3页Guangxi Medical Journal

基　　金：广西医药卫生科研课题(Z2016230)

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者血清可溶性人基质裂解素2(s ST2)的表达水平及其临床意义。方法选择100例COPD患者,其中COPD急性加重期50例(加重组),COPD稳定期50例(稳定组),另取健康志愿者50例(对照组)作为研究对象。采用酶联免疫吸附法检测3组受试者血清s ST2、白细胞介素33(IL-33)、干扰素γ(INF-γ)水平,采用肺功能仪测定1秒用力呼气容积占用力肺活量百分比(FEV1/FVC)、1秒用力呼气容积占预计值的百分比(FEV1%pred)。结果加重组患者血清s ST2、IL-33及INF-γ水平高于稳定组和对照组(P <0. 05),稳定组患者血清IL-33高于对照组(P <0. 05)。相关分析结果显示,加重组和稳定组患者血清s ST2水平与IL-33呈正相关(P <0. 05),而与INF-γ、FEV1/FVC及FEV1%pred均呈负相关(均P <0. 05)。结论加重期COPD患者血清s ST2水平呈高表达,其或可作为判断COPD预后的一项临床检测指标。Objective To investigate the expression level and its clinical significance of serum soluble suppression of tumorigenicity2(s ST2)in the patients with chronic obstructive pulmonary disease(COPD).Methods One hundred patients with COPD,including 50 patients with acute exacerbation of COPD(exacerbation group)and 50 patients with stable COPD(stable group),and another50healthy volunteers(control group)were enrolled as the subjects.Enzyme-linked immunosorbent assay was used to detect the levels of serum s ST2,interleukin33(IL-33),interferon gamma(INF-γ)of the subjects in the three groups,and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)and the percentage of predicted forced expiratory volume in one second(FEV1%pred)were determined by the spirometry calibration device.Results The serum levels of s ST2,IL-33and INF-γin the exacerbation group were higher than those in the stable group and the control group(P<0.05),and the serum IL-33level in the stable group was higher than that in the control group(P<0.05).The result of correlation analysis showed that serum s ST2level positively correlated with IL-33but negatively correlated with INF-γ,FEV1/FVC and FEV1%pred in the patients of the exacerbation group and the stable group(all P<0.05).Conclusion High expression level of serum s ST-2is seen in the patients with acute exacerbation of COPD,which might be used as a clinical detection indicator for assessing the prognosis of COPD.

关 键 词：慢性阻塞性肺疾病 可溶性人基质裂解素2 干扰素Γ 白细胞介素33 病情严重程度 肺功能 预后 

分 类 号：R563[医药卫生—呼吸系统]