RNA结合蛋白Rbm24的功能研究进展  

Research Progress of the Role of RNA-binding Protein Rbm24a

作　　者：孔淑慧 成海建[1,2,3] 姜富贵 王亚芳[1,2,3] 张清峰 宋恩亮 KONG Shu-hui;CHENG Hai-jian;JIANG Fu-gui;WANG Ya-fang;ZHANG Qing-feng;SONG En-liang(Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No.8, Jinan 250100, China;Shandong Key Lab of Animal Disease Control and Breeding, Sangyuan Road No. 8, Jinan 250100,China;Shandong Provincial Engineering Technology Center of Animal Healthy Breeding, Sangyuan Road No. 8, Jinan 250100, China)

机构地区：[1]山东省农业科学院畜牧兽医研究所,济南250100 [2]山东省畜禽疫病防治与繁育重点实验室,济南250100 [3]山东省畜禽健康养殖工程技术中心,济南250100

出　　处：《草食家畜》2018年第6期1-7,共7页Grass-Feeding Livestock

基　　金：国家科技支撑计划项目(2015BAD03B04);转基因生物新品种培育计划子课题(2016ZX08007-002);现代农业(肉牛牦牛)产业技术体系建设专项资金(CARS-37)

摘　　要：RNA结合蛋白作为转录后调控因子对调节RNA代谢和基因表达有重要作用。RNA结合蛋白Rbm24(RNA Binding Motif Protein 24)是RNA结合蛋白家族的一员,在其N末端有一个保守的RNA识别基序(RNA Recognization Motif,RRM)。Rbm24在心脏和骨骼肌的分化和发育、抗癌、抗巨肠症、调控病毒复制等方面发挥关键作用。Rbm24对转录后的调控主要是通过调控靶基因mRNA稳定性或可变剪接调节靶基因的表达。RNA-binding proteins,as the post-transcriptional regulators,play an important role for regulating RNA metabolism and gene expression.As a member of the RNA-binding protein family,Rbm24has a single RNA-Recognition Motif(RRM)in its N-terminal region.Rbm24is crucial in the differentiation and development of cardiac and skeletal muscle,cancer,megacolon and virus replication.The post-transcription regulation of Rbm24in the expression of target genes is mainly shown by regulating the mRNA stability or tissue-specific alternative splicing events.

关 键 词：RNA结合蛋白 Rbm24 MRNA稳定性 可变剪接 

分 类 号：Q344[生物学—遗传学]