依维莫司药物洗脱支架的发展进程  

Development of everolimus-eluting stents

作　　者：凌浩 王宝 吴莉侠[1] 闫会 宋春莉[1] Ling Hao;Wang Bao;Wu Lixia;Yan Hui;Song Chunli(Department of Cardiovascular Medicine, Second Hospital of Jilin University, Changchun 130012, Jilin Province, China;Department of Internal Medicine, Dongliao People’s Hospital, Liaoyuan 136600, Jilin Province, China)

机构地区：[1]吉林大学第二医院心血管内科,吉林省长春市130012 [2]吉林省辽源市东辽县人民医院内科,吉林省辽源市136600

出　　处：《中国组织工程研究》2019年第6期978-984,共7页Chinese Journal of Tissue Engineering Research

基　　金：吉林省发改委产业技术研究与开发项目(2016C044-2);项目负责人:宋春莉;吉林省教育厅十三五科学技术研究项目(JJKH20180104KJ);项目负责人:宋春莉;吉林省财政厅卫生专项项目;项目负责人:宋春莉;吉林省新型冠脉支架科技创新中心(JKFC2017250);项目负责人:宋春莉~~

摘　　要：背景:药物洗脱支架将金属支架的机械支架性能与一种抗增殖药物的特异性结合起来,能够有效的减少支架对血管的损伤、支架内再狭窄和血栓的发生率,并降低晚期不良事件的风险。目的:探索依维莫司药物洗脱支架研究进展。方法:以"依维莫司;everolimus;stent;drug-eluting stents;everolimus drug-eluting stents"等为关键词,在中国知网数据库、PubMed、EMBAES数据库中进行检索,排除与文章不相关的、老旧的、重复的文献,对保留的61篇文献进行归纳、分析与总结。结果与结论:依维莫司药物洗脱支架目前临床上以钴铬依维莫司药物洗脱支架最为常见,可有效抑制内膜增生和炎症反应发生,减少支架内血栓的发生率。虽然新型依维莫司药物洗脱支架的出现解决了依维莫司药物洗脱支架的一些问题,如血小板黏附、平滑肌细胞增殖、血管舒缩及血管内皮细胞活性,但还有一些问题需要继续研究。BACKGROUND:Drug-eluting stents,which combine the mechanical properties of metal stents with the specificity of an anti-proliferative drug,can effectively reduce the incidence of stent injury,restenosis and thrombosis,and reduce the risk of late adverse events.OBJECTIVE:To review the progress of everolimus-eluting stents.METHODS:The key words of“everolimus,stent,drug-eluting stents,everolimus drug-eluting stents”were used for literature retrieval in CNKI,PubMed and EMBASE databases.Unrelated,old and duplicated literatures were excluded,and61retained literatures were summarized,analyzed and summarized.RESULTS AND CONCLUSION:Cobalt chromium-everolimus eluting stent is the most common everolimus-eluting stent,which can effectively inhibit intimal hyperplasia and inflammation and reduce the incidence of stent thrombosis.Although the emergence of new everolimus-eluting stents has solved some problems of existing everolimus-eluting stents,such as platelet adhesion,smooth muscle cell proliferation,vasomotion and vascular endothelial cell viability,there are still some problems that need to be further studied.

关 键 词：依维莫司 钴铬合金 药物洗脱 血管支架 冠状动脉粥样硬化性心脏病 血小板黏附 支架内再狭窄 冠状动脉疾病 支架 组织工程 

分 类 号：R452[医药卫生—治疗学] R318[医药卫生—临床医学]