匹多莫德辅助治疗对手足口病患儿T淋巴细胞亚群和炎症因子的影响  

Effect of Pidotimod Adjuvant Therapy on T lymphocyte Subsets and Inflammatory Factors in Children with Hand Foot Mouth Disease

作　　者：张进军[1] 吴胜会[1] 刘科贝[1] ZHANG Jinjun;WU Shenghui;LIU Kebei(Xi'an Children's Hospital,Shaanxi Xi'an 710003,China)

机构地区：[1]陕西省西安市儿童医院,陕西西安710003

出　　处：《河北医学》2018年第12期1973-1978,共6页Hebei Medicine

基　　金：陕西省自然科学基金项目;(编号:20131054)

摘　　要：目的:研究匹多莫德辅助治疗对手足口病患儿T淋巴细胞亚群和炎症因子的影响。方法:将西安市儿童医院收治的800例手足口病患儿根据入院顺序分为观察组和对照组,400例每组。对照组采用利巴韦林,观察组联合匹多莫德进行治疗。比较两组患儿疱疹消退时间、体温恢复正常时间、住院时间,T淋巴细胞亚群,炎症因子,免疫球蛋白。结果:观察组疱疹消退时间、体温恢复正常时间、住院时间显著少于对照组(P<0.05)。治疗前,两组患儿CD3+、CD4+、CD8+、CD4+/CD8+细胞比值比较无显著差异(P>0.05),治疗后,观察组的CD3+、CD4+、CD8+、CD4+/CD8+细胞比值显著高于对照组(P<0.05)。治疗前,两组患儿IL-6、IL-10、IL-1β、TNF-α水平比较无显著差异(P>0.05),治疗后,观察组IL-6、IL-1β、TNF-α水平显著低于对照组(P <0.05),IL-10水平显著高于对照组(P <0.05)。治疗前,两组患儿IgA、IgG、IgM水平比较无显著差异(P>0.05),观察组的IgA、IgG水平显著高于对照组(P <0.05)。结论:匹多莫德辅助治疗能有效改善手足口病患儿T淋巴细胞免疫功能和炎症因子,促使患儿病情恢复,临床疗效良好。Objective:To study the effect of pidotimod in treatment of children with hand-foot disease and its effects on T lymphocyte subsets and inflammatory factors.Methods:800 children with hand-foot-mouth disease admitted to Xi'an Children's Hospital were divided into observation group and control group according to the order of admission,400 cases in each group.The control group was treated with ribavirin,and the observation group was treated with pidotimod.The herpes elimination time,body temperature return time,hospital stay,T-lymphocyte subsets,inflammatory factors,and immunoglobulin were compared between the two groups.Results:The herpes elimination time,normal body temperature return time,and length of stay in the observation group were significantly less than those in the control group(P<0.05).Before treatment,there was no significant difference in the CD3+,CD4+,CD8+,and ratios of CD4+/CD8+cells between the two groups(P>0.05).After treatment,the CD3+,CD4+,CD8+,and ratios of CD4+/CD8+cells in the observation group were significantly higher than those in the control group(P<0.05).Before treatment,there was no significant difference in the levels of IL-6,IL-10,IL-1βand TNF-αbetween the two groups(P>0.05).After treatment,the levels of IL-6,IL-1βand TNF-αin the observation group were significantly lower than the control group(P<0.05),IL-10 levels were significantly higher than the control group(P<0.05).Before treatment,the levels of IgA,IgG,and IgM in the two groups were not significantly different(P>0.05).The IgA and IgG levels in the observation group were significantly higher than those in the control group(P<0.05).Conclusion:Pidotimod adjuvant therapy can effectively improve T lymphocyte immune function and inflammatory factors in children with hand-foot and mouth disease,and promote the recovery of children disease,with good clinical efficacy.

关 键 词：匹多莫德 手足口病 T淋巴细胞 炎症因子 

分 类 号：R725.1[医药卫生—儿科]