分子印迹聚合物修饰氧化石墨烯用于选择性识别槲皮素（英文）  

A molecularly-imprinted polymer decorated on graphene oxide for the selective recognition of quercetin

作　　者：赵小峰 段菲菲[1] 崔培培 杨永珍[1,3] 刘旭光 侯相林[4] ZHAO Xiao-feng;DUAN Fei-fei;CUI Pei-pei;YANG Yong-zhen;LIU Xu-guang;HOU Xiang-lin(Key Laboratory of Interface Science and Engineering in Advanced Materials(Taiyuan University of Technology), Ministry of Education,Taiyuan030024,China;College of Chemistry and Chemical Engineering,Taiyuan University of Technology,Taiyuan030024,China;Research Center on Advanced Materials Science and Technology,Taiyuan University of Technology,Taiyuan030024,China;Shanxi Engineering Research Center of Biorefinery,Institute of Coal Chemistry,Chinese Academy of Sciences,Taiyuan030001,China)

机构地区：[1]太原理工大学新材料界面科学与工程教育部重点实验室,山西太原030024 [2]太原理工大学化学化工学院,山西太原030024 [3]太原理工大学新材料工程技术研究中心,山西太原030024 [4]中国科学院山西煤炭化学研究所山西省生物炼制工程技术研究中心,山西太原030001

出　　处：《新型炭材料》2018年第6期529-543,共15页New Carbon Materials

基　　金：National Natural Science Foundation of China(U1610255,U1607120);Shanxi Provincial Key Innovative Research Team in Science and Technology(2015013002-10,201605D131045-10);Postgraduate Innovation Program of Shanxi Province(2016SY018)~~

摘　　要：利用分子模拟技术设计槲皮素(Qu)印迹预组装体系,确定功能单体的种类及其与Qu的作用比例;在此基础上,采用自由基聚合法制备分子印迹聚合物修饰的氧化石墨烯(GO/MIP),并通过傅里叶变换红外光谱仪、元素分析仪、拉曼光谱仪、热重分析仪、扫描电子显微镜和原子力显微镜系统分析所制GO/MIP复合材料的形貌和结构。静态吸附实验的结果表明,在298 K下,GO/MIP复合材料对Qu的动力学吸附平衡时间和吸附量分别为30 min和30. 61 mg g^(-1)。此外,准二级动力学模型和Langmuir吸附等温模型可较好地描述GO/MIP复合材料对Qu的吸附行为。混合黄酮类化合物溶液中进行的竞争吸附实验的结果说明,相对Qu而言,GO/MIP复合材料对结构类似物山奈酚和芦丁的相对选择性系数分别为1. 966和3. 557。所制GO/MIP复合材料提高了表面MIPs用于选择性识别多酚类化合物的能力,为制备用于天然产物中特异性检测和快速分离黄酮的表面MIPs提供指导意义。A molecularly-imprinted polymer decorated on graphene oxide(GO/MIP)was designed with the aid of molecular modeling to select an appropriate functional monomer and to optimize its ratio to an imprinting molecule of quercetin(Qu)for the selective adsorption of Qu.The GO/MIP was prepared by free radical polymerization on the surface of GO using a functional monomer of 4-vinylpyridine at its optimal molar ratio to Qu of 4∶1.The GO/MIP was characterized by Fourier transform infrared spectroscopy,elemental analysis,Raman spectroscopy,thermogravimetric analysis,scanning electron microscopy,atomic force microscopy and adsorption measurements.Results indicate that the equilibrium time and adsorption capacity of the GO/MIP towards Qu are 30 min and 30.61 mg g-1 at 298 K,respectively and the adsorption data are well described by a pseudo-second-order kinetic model and the Langmuir isotherm model.From competing adsorption tests in a solution containing three flavonoids(Qu,kaempferol and rutin),the GO/MIP displays an excellent recognition ability for Qu with faster adsorption kinetics than bulk MIP without GO,and has highest adsorption capacity and selectivity for Qu among the three flavonoids,which is superior to un-imprinted polymer.

关 键 词：氧化石墨烯 分子印迹聚合物 槲皮素 黄酮类 密度泛函理论 

分 类 号：TB33[一般工业技术—材料科学与工程]