右美托咪定对神经外科脊髓疾病术中唤醒效果影响分析  

Effect of dexmedetomidine on awakening effect of neurosurgical spinal cord disease during operation

作　　者：王海燕 鲁彦斌 杜建龙 蒋留琴 雷国栋 高怀新 黄海燕 陈尚军 WANG Hai-yan;LU Yan-bin;DU Jian-long;JIANG Liu-qin;LEI Guo-dong;GAO Huai-xin;HUANG Hai-yan;CHEN Shang-jun(Shaanxi Provincial Nuclear Industry 215 Hospital Department of Anesthesiology;Shaanxi Provincial Nuclear Industry 215 Hospital Department of Neurosurgery ,Xianyang 712000 , China)

机构地区：[1]陕西省核工业二一五医院麻醉科 [2]陕西省核工业二一五医院神经外科,陕西咸阳712000

出　　处：《延安大学学报（医学科学版）》2018年第4期67-69,共3页Journal of Yan'an University:Medical Science Edition

摘　　要：目的观察右美托咪定对脊髓疾病术中唤醒时间和质量的影响。方法将37例神经外科脊髓手术的患者随机分成治疗组:右美托咪定维持组,对照组:生理盐水维持组。两组均采用全凭静脉麻醉,治疗组术中持续静脉泵注右美托咪定0. 2μg/kg·h,对照组给予同剂量生理盐水,观察两组患者唤醒前5 min(T1)、自主呼吸恢复(T2),唤醒即刻(T3),和唤醒后5 min(T4),心率、平均动脉压和脑电双频指数变化,并比较两组唤醒时间、唤醒质量及唤醒时躁动情况。结果两组唤醒即刻,唤醒后5 min,心率、平均动脉压高于唤醒前5 min(P <0. 05),治疗组唤醒质量高于对照组(P <0. 05);两组唤醒即刻躁动情况、唤醒期间脑电双频指数比较,差异有统计学意义(P <0.05)。结论右美托咪定不延迟术中唤醒时间,且唤醒期间血流动力学平稳,躁动发生率减少,用于脊柱脊髓手术术中唤醒安全、有效。Objective To observe the effect of dexmedetomidine on the wake-up time and quality of spinal cord disease during surgery.Methods Thirty-seven patients undergoing neurosurgical spinal surgery were randomly divided into treatment group:dexmedetomidine maintenance group,control group:saline maintenance group.All the two groups were treated with total intravenous anesthesia.The patients in the treatment group were treated with continuous venous injection of dexmedetomidine0.2μg/kgh.The control group was given the same dose of normal saline.The two groups were observed for5minutes before the awakening(T1)and spontaneous breathing.Recovery(T2),immediate awakening(T3),and5minutes after awakening(T4),heart rate,mean arterial pressure,and bispectral index changes,and comparing two groups of wake-up time,wake-up quality,and arousal during arousal.Results The arousal of the two groups was immediately aroused.After5minutes of awakening,the heart rate and mean arterial pressure were higher than those before the awakening(P<0.05).The arousal quality of the treatment group was higher than that of the control group(P<0.05).The two groups aroused the immediate agitation and wake-up period.The difference in bispectral index was statistically significant(P<0.05).Conclusion Dexmedetomidine does not delay the intraoperative wake-up time,and the hemodynamics is stable during awakening,and the incidence of agitation is reduced.It is safe and effective for arousal in spinal spinal surgery.

关 键 词：右美托咪定 脊髓手术 术中唤醒 

分 类 号：R614.27[医药卫生—麻醉学]