苦黄注射液联合异甘草酸镁对急性黄疸型病毒性肝炎患者的疗效观察  

Effects of Kuhuang Injection Combined with Magnesium Isoglycyrrhizinate on Patients with Acute Jaundice Viral Hepatitis

作　　者：马晓华 杨淑娟 姜娜 闫瑞蕊 李飞宇 王裕云 刘小毛 Ma Xiaohua;Yang Shujuan;Jiang Na;Yan Ruirui;Li Feiyu;Wang Yuyun;Liu Xiaomao(Eighth Hospital of Xi′an City,Xi′an 710061,China;First People′s Hospital of Xianyang City,Xianyang 712000,China)

机构地区：[1]陕西省西安市第八医院,西安710061 [2]陕西省咸阳市第一人民医院,咸阳712000

出　　处：《世界中医药》2018年第12期2991-2994,共4页World Chinese Medicine

基　　金：陕西省重点研发计划项目(2017SF-243)

摘　　要：目的:观察苦黄注射液联合异甘草酸镁对急性黄疸型病毒性肝炎患者症状改善、血清炎性因子和丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、直接胆红素(DBIL)水平的影响。方法:选取2014年1月至2017年1月西安市第八医院收治的急性黄疸型病毒性肝炎患者180例,随机分为对照组和观察组,每组90例,对照组应用异甘草酸镁治疗,观察组应用苦黄注射液联合异甘草酸镁治疗,2组均持续治疗2周。比较2组治疗后临床疗效,记录2组治疗前后症状改善情况,检测2组治疗前后血清炎性因子、肝功能指标和氧化应激水平。结果:治疗后观察组临床治疗总有效率显著高于对照组(P <0. 05); 2组治疗后中医症状积分、血清白细胞介素-6 (IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、ALT、TBIL、DBIL水平以及丙二醛(MDA)含量均较治疗前显著下降(P <0. 05),且观察组上述指标降低程度均显著优于对照组(P <0. 05); 2组治疗后超氧化物歧化酶(SOD)活性均较治疗前显著上升(P <0. 05),且观察组SOD活性升高程度显著优于对照组(P <0. 05)。结论:苦黄注射液联合异甘草酸镁治疗急性黄疸型病毒性肝炎患者,能明显改善症状、降低血清炎性因子和肝功能指标水平。Objective:To observe the effects of Kuhuang Injection combined with magnesium isoglycyrrhizinate on symptoms improvement,serum inflammatory factors,alanine aminotransferase(ALT),total bilirubin(TBIL)and direct bilirubin(DBIL)levels in patients with acute jaundice viral hepatitis.Methods:A total of 180 patients with acute jaundice viral hepatitis treated in the Eighth Hospital of Xi′an City from January 2014 to January 2017 were selected and randomly divided into control group and observation group,each with 90 cases.The control group was treated with magnesium isoglycyrrhizinate,and 90 cases in the observation group were treated with Kuhuang Injection combined with magnesium isoglycyrrhizinate.Both the two groups were treated for 2 weeks.The clinical efficacy after treatment was compared between the two groups.Symptomatic improvement was recorded before and after treatment in the 2 groups.The levels of serum inflammatory factors,liver function indexes and oxidative stress were detected before and after treatment in the 2 groups.Results:After treatment,the total effective rate of the observation group was significantly higher than that of control group(P<0.05).The traditional Chinese medicine(TCM)symptom score,serum interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α)and high sensitive C reactive protein(hs-CRP),ALT,TBIL,DBIL levels and malondialdehyde(MDA)content of the 2 groups after treatment were significantly decreased than before treatment(P<0.05),and the decreasing degree of above indexes in observation group was superior to those in the control group(P<0.05).The activity of superoxide dismutase(SOD)in both groups was significantly increased after treatment(P<0.05),and it in the observation group was increased more significantly than that in the control group.Conclusion:Kuhuang Injection combined with magnesium isoglycyrrhizinate in the treatment of acute jaundice viral hepatitis can obviously improve the symptoms,reduce the levels of serum inflammatory factors and liver function indexes.

关 键 词：苦黄注射液 异甘草酸镁 急性黄疸型病毒性肝炎 炎性因子 肝功能 

分 类 号：R256.4[医药卫生—中医内科学]