自拟中药治疗对重症胰腺炎患者胰腺微循环指标的影响  

Effects of Modified Chinese Medicine Formula on the Index of Pancreatic Microcirculation in Patients with Severe Pancreatitis

作　　者：李新荣 柯传虎 Li Xinrong;Ke Chuanhu(Gastroenterology Department,Zhongshan Nanlang Hospital,Zhongshan 528451,China;Chinese Medicine Department,Zhongshan Nanlang Hospital,Zhongshan 528451,China)

机构地区：[1]广东省中山市南朗医院消化内科,中山528451 [2]广东省中山市南朗医院中医科,中山528451

出　　处：《世界中医药》2018年第12期2995-2998,共4页World Chinese Medicine

基　　金：广东省中医药局科研课题(20151216)

摘　　要：目的:探究自拟中药治疗对重症胰腺炎患者胰腺微循环指标的影响。方法:选取2015年1月至2017年5月中山市南朗医院收治确诊为重症胰腺炎患者63例,按照随机数字表法分为对照组与观察组,每组32例,对照组患者给予肠胃减压、抗感染、纠正电解质平衡、止痛等常规治疗与注射生长抑素治疗,观察组患者在对照组的基础上给予加减柴苓承气汤治疗,比较2组临床疗效与胰腺微循环指标变化。结果:观察组患者临床有效率明显高于对照组,差异有统计学意义(P <0. 05),观察组患者腹痛、体温过高、肠鸣音异常症状恢复正常时间以及住院时间均短于对照组,差异有统计学意义(P>0. 05),治疗后,观察组患者胰腺血流量高于对照组,差异有统计学意义(P <0. 05),血浆黏度观察组则低于对照组,差异有统计学意义(P <0. 05);治疗后观察组患者血清血栓素B2(TXB2)、血小板α颗粒膜蛋白(GMP-140)、血清内皮素-1(ET-1)均低于对照组,差异有统计学意义(P <0. 05),血清一氧化氮(NO)水平则高于对照组,差异有统计学意义(P <0. 05)。结论:在加减柴苓承气汤的基础上自拟中药治疗方剂联合常规治疗可有效改善重症胰腺炎患者胰腺微循环状态,临床疗效显著。Objective:To explore the effects of traditional Chinese medicine on the index of pancreatic microcirculation in patients with severe pancreatitis.Methods:A total of 63 cases of severe pancreatitis diagnosed in Zhongshan Nanlang Hospital from January 2015 to May 2017 were selected as the research object.According to the random number table method,all patients were divided into control group(n=31)and observation group(n=32).The control group were treated with gastrointestinal decompression,anti-infection,correction of electrolyte balance,pain relief and other conventional treatment with somatostatin injection treatment,while observation group were given modified Chailing Chengqi Decoction on the basis of the control group.Then the clinical curative effect and the changes of pancreatic microcirculation index of two groups were compared.Results:The clinical effective rate in observation group was significantly higher than that in control group(P<0.05).In observation group,the patients′recovery time who had abdominal pain,hyperthermia and bowel sounds and the hospitalized period was shorter than those in the control group(P>0.05).After treatment,the pancreatic blood flow in observation group was higher than that in control group(P<0.05),and the plasma viscosity in observation group was lower than that in control group(P<0.05).The levels of TXB 2,GMP-140 and ET-1 in the observation group were lower than those in control group(P<0.05),and the serum NO levels were higher than those in control group(P<0.05).Conclusion:The modified decoction based on Chailing Chengqi Decoction on the treatment of traditional Chinese medicine prescription combined with conventional therapy can effectively improve the patients with severe acute pancreatitis of pancreatic microcirculation.

关 键 词：中药 重症胰腺炎 胰腺微循环 临床疗效 常规治疗 炎性反应递质 柴苓承气汤 血浆黏度 

分 类 号：R289.5[医药卫生—方剂学] R576[医药卫生—中药学]