肾炎四味片对慢性肾小球肾炎患者免疫功能及炎性反应指标的影响  

Clinical Efficacy of Nephritis Siwei Tablet on Chronic Glomerulonephritis and Its Influence on Immune Function and Inflammation Indexes

作　　者：谭艳菊 宋羽 何炳洪 Tan Yanju;Song Yu;He Binghong(Drug and Equipment Section,Affiliated Renhe Hospital of China Three Gorges University,Yichang 443001,China;Department of Pharmacy,the Third Affiliated Hospital of Southern Medical University,Guangzhou 510630,China)

机构地区：[1]三峡大学附属仁和医院药械科,宜昌443001 [2]南方医科大学第三附属医院药学部,广州510630

出　　处：《世界中医药》2018年第12期3062-3065,共4页World Chinese Medicine

基　　金：2017年度广东省广州市科技计划项目(201704KW036)

摘　　要：目的:探讨肾炎四味片对慢性肾小球肾炎(CGN)的临床疗效及对免疫功能和炎性反应指标的影响。方法:选取2015年2月至2017年5月三峡大学附属仁和医院收治的CGN患者116例,按照随机数字表法随机分为观察组和对照组,每组58例,2组均给予控制血压、限制饮食等常规治疗,对照组给予贝那普利口服,观察组给予肾炎四味片治疗。比较2组临床疗效、治疗前后血清炎性因子水平、24 h尿蛋白定量(24 h pro)及免疫功能变化。结果:治疗后观察组总有效率为93. 10%,显著高于对照组的79. 31%(P <0. 05)。与治疗前比较,治疗后2组Lkn-1、TNF-α、24 h尿蛋白及观察组IL-6和IL-8水平均明显降低(P <0. 05或P <0. 01),且观察组显著低于对照组(P <0. 05或P <0. 01)。与治疗前比较,治疗后观察组CD3+、CD4+比例及CD4+/CD8+均明显升高(P <0. 01),CD8+比例明显降低(P <0. 01),与对照组比较,差异均有统计学意义(均P <0. 01)。结论:肾炎四味片可以降低CGN患者血清炎性因子水平及24 h尿蛋白,控制炎性反应进展,改善机体免疫功能,提高临床治疗效果。Objective:To study the clinical efficacy of Nephritis Siwei Tablet on chronic glomerulonephritis(CGN)and its influence on immune function and inflammation indexes.Methods:A total of 116 CGN cases in Affiliated Renhe Hospital of China Three Gorges University from February 2015 to May 2017 were selected and randomly divided into observation group and control group with 58 cases in each group.The 2 groups were given conventional treatment such as controlling blood pressure,limiting diet and other conventional treatment.The control group was given Benazepril,and the observation group was given Nephritis Siwei Tablet.The 2 groups were continuously treated for 2 months.The clinical efficacy,the levels of serum inflammatory factors,the 24 h urinary protein quantification(24 h pro)and immune function of 2 groups were compared before and after treatment.Results:The total effective rate was 93.10%in the observation group,which was significantly higher than 79.31%in the control group(P<0.05).Compared with the data before treatment,the levels of Lkn-1,TNF-α,24 h pro in 2 groups and IL-6,IL-8 in observation group after treatment significantly decreased,and the observation group was significantly lower than those of the control group(P<0.05 or P<0.01).Compared with the data before treatment,the ratio of CD3+,CD4+and CD4+/CD8+in the observation group significantly increased,and the ratio of CD8+significantly decreased.The difference was statistically significant compared with the control group(P<0.01).Conclusion:Nephritis Siwei Tablet can reduce the levels of serum inflammatory factors and 24 h pro in CGN patients,control the progress of inflammation,improve the immune function of the body,and enhance the clinical efficacy.

关 键 词：慢性肾小球肾炎 肾炎四味片 疗效 炎性因子 免疫功能 

分 类 号：R259[医药卫生—中西医结合]