降脂合剂对高脂血症大鼠血脂代谢、低密度脂蛋白氧化易感性及血液黏浓聚凝状态的影响  

Effects of Lipid-lowering Mixture on Blood Lipid Metabolism,LDL Oxidation Susceptibility and Blood Viscosity and Coagulation in Experimental Hyperlipidemia Rats

作　　者：梁泽明[1] 贾军正[1] 曹瑞 Liang Zeming;Jia Junzheng;Cao Rui(Baoji Hospital of Traditional Chinese Medicine,Baoji 721000,China;Xingyuan Hospital of Yulin City in Shaanxi province,Yulin 719000,China)

机构地区：[1]陕西省宝鸡市中医医院心内科,宝鸡721000 [2]陕西省榆林市星元医院心内科,榆林719000

出　　处：《世界中医药》2018年第12期3099-3102,共4页World Chinese Medicine

基　　金：陕西省自然科学发展项目(XZ-423H)

摘　　要：目的:探讨降脂合剂对高脂血症大鼠血脂代谢、低密度脂蛋白(LDL)氧化易感性及血液黏浓聚凝状态的影响。方法:选取雄性Wistar大鼠60只并随机分为6组,每组10只,分别记为降脂合剂低、中、高剂量组和辛伐他汀组、模型组以及对照组。其中对照组采用基础饲料进行喂养,其他各组均采用高脂饲料进行喂养建立高脂血症大鼠模型,同时进行预防给药,测定各组10周后的血脂代谢、LDL氧化易感性及血液黏浓聚凝状态。结果:模型组的血清低密度脂蛋白胆固醇(LDL-C)抗氧化能力明显降低,而辛伐他汀组和3组降脂合剂组的血清LDL抗氧化能力均明显增强;并且降脂合剂高、中剂量组的LDL抗氧化能力均明显高于降脂合剂低剂量组,差异有统计学意义(P <0. 05)。降脂合剂高、中剂量组对红细胞电泳时间(EET)和ηp、ηb(高、中、低切)、红细胞变形指数(IED)、红细胞压积(HCT)、红细胞聚集指数(IEA)、红细胞电泳时间(EET)、红细胞变形指数(IED)的作用均显著强于降脂合剂低剂量组,差异有统计学意义(P <0. 05)。结论:降脂合剂对于实验性高脂血症大鼠的血脂代谢以及血液黏浓聚凝状态具有较好的调节作用,同时降脂合剂在血脂和血流异常方面降脂合剂还能够起到不错的调节和治疗效果。Objective:To investigate the effects of lipid-lowering mixture on blood lipid metabolism,LDL oxidative susceptibility and blood viscosity and coagulation in experimental hyperlipidemia rats.Methods:A total of 60 male Wistar rats were selected and randomly divided into 6 groups,with 10 rats in each group,which were divided as low,middle and high lipid-lowering mixture dose group and simvastatin group,model group and control group.The control group was fed with basal diet,other groups of rats were fed with high fat diet to establish hyperlipidemia rats model.Prophylactic administration was simultaneously performed during the modeling process,and lipid metabolism,LDL oxidative susceptibility,and blood coagulation state were measured 10 weeks after the rats in each group.Results:The antioxidant capacity of serum LDL-C in the model group rats was decreased significantly,and LDL serum antioxidant capacity in simvastatin group and three groups of lipid-lowering mixture group was significantly enhanced,and the antioxidant capacity of LDL in the high and middle lipid-lowering mixture dose groups was significantly superior to that in the middle dose group(P<0.05).The effects of high and middle lipid-lowering mixture groups on EET and ETA p,ETA B(high,medium and low shear),IED,HCT,the role of the IEA were superior to those of low lipid-lowering mixture group(P<0.05 or P<0.05).Conclusion:Lipid-lowering mixture can effectively regulate the blood lipid metabolism and blood viscosity concentration coagulation state in experimental hyperlipidemia rat,which also has a good regulation effect on lipid-lowering mixture in blood lipid and blood flow abnormality and curative effect.

关 键 词：高脂血症 降脂合剂 血脂代谢 血液黏浓聚凝状态 载脂蛋白 

分 类 号：R289.5[医药卫生—方剂学]