阻塞性睡眠呼吸暂停低通气综合征患者血清癌胚抗原和T淋巴细胞亚群水平变化及其相关性  

Study on the changes and correlation of serum CEA and T lymphocyte subsets in patients with obstructive sleep apnea-hypopnea syndrome

作　　者：吴良宁[1] 郑丽钦 林国盛[1] 陈国欢[1] 林群英[1] Wu Liangning;Zheng Liqin;Lin Guosheng;Chen Guohuan;Lin Qunying(Department of Respiratory,Affiliated Hospital(Group)of Putian University,Putian 351100,China)

机构地区：[1]莆田学院附属医院呼吸与危重症医学科,福建351100

出　　处：《中华肺部疾病杂志（电子版）》2018年第6期689-696,共8页Chinese Journal of Lung Diseases(Electronic Edition)

基　　金：福建省自然科学基金资助项目(2018J01196);莆田市科技计划项目(2013S03(1))

摘　　要：目的分析成人阻塞性睡眠呼吸暂停低通气综合征(OSAHS),探讨OSAHS患者癌胚抗原(CEA)水平变化与T淋巴细胞亚群(T-LS)水平变化的相关性。方法选择2015年3月至2017年1月期间我院呼吸内科门诊及住院确诊为OSAHS的患者85例为OSAHS组,按病情的严重程度将患者分为轻度组、中度组、重度组,按病程长短将患者分为长病程组(>5年)和短病程组(<5年),同期选择门诊健康体检者32例作为对照组。检测所有研究对象外周血清CEA和T-LS水平,比较各组之间外周血清CEA和T-LS水平的差异。同时记录所有研究对象多导图睡眠监测中呼吸暂停低通气指数(AHI)和最低血氧饱和度(LSaO_2)监测结果,分析OSAHS患者外周血清CEA、T-LS、AHI及LSaO_2之间的关系。结果OSAHS组患者血清CD3^+CD4和CD4^+/CD8^+明显下降(P<0.05),且病情越重病程越长下降越明显;重度组和长病程组OSAHS患者CEA水平升高(P<0.05); OSAHS组患者CD3^+CD4^+与AHI、LSaO_2和CEA均存在显著相关性(P<0.01),其中与AHI和CEA水平呈负相关,与LSaO_2呈正相关; CD3^+CD8^+与AHI、LSaO_2均存在相关性(P<0.05),其中与AHI呈正相关,与LSaO_2呈负相关; OSAHS组患者血清CEA水平与AHI、LSaO_2均存在显著相关性(P<0.01),其中与AHI呈正相关,与LSaO_2呈负相关。结论OSAHS患者可能存在不同程度的免疫功能下降和血清CEA水平升高,其CEA水平升高可能与其免疫功能下降有关; AHI和LSaO_2可能也是影响OSAHS患者免疫功能和CEA水平的因素之一。Objective To analyze the changes of serum carcinoembryonic antigen(CEA)and T lymphocyte subsets(T-LS)levels in adult patients with obstructive sleep apnea-hypopnea syndrome(OSAHS),and to explore whether the changes of CEA levels in patients with OSAHS are related to the changes of T-LS levels.Methods Choose during March 2015 to January 2017,our hospital respiratory medicine clinic and hospital diagnosis of OSAHS patients,85 cases of OSAHS group,the patients were divided into mild group,moderate group and severe group according to the severity of the disease,and the patients were divided into long course group(>5 years)and short course group(<5 years)according to the duration of disease,32 healthy outpatients were selected as control group.The peripheral serum CEA and T-LS were detected in all the subjects,and the differences of serum CEA and T-LS were compared.At the same time,we recorded the AHI and LSaO2 monitoring results of all subjects in PSG monitoring,analyzed the relationship between serum CEA,T-LS,AHI and LSaO2 in patients with OSAHS.Results the serum CD3^+CD4^+and CD4^+/CD8^+of patients in group OSAHS were significantly decreased(P<0.05),and the more severe the disease,the longer the course of disease,the more obvious;The level of CEA increased in patients with severe and long course of OSAHS(P<0.05);There was a significant correlation between CD3^+CD4^+and AHI,LSaO2 and CEA in OSAHS group(P<0.01),which was negatively correlated with AHI and CEA,and positively correlated with LSaO2;CD3^+CD8^+was correlated with AHI and LSaO2(P<0.05),which was positively correlated with AHI and negatively correlated with LSaO2;There was a significant correlation between serum CEA level and AHI,LSaO2 in OSAHS group(P<0.01),which was positively correlated with AHI and negatively correlated with LSaO2.Conclusion OSAHS patients may have different levels of immune function decline and elevated serum CEA levels;The increase of CEA level may be related to the decrease of immune function.AHI and LSaO2 may be one of the factors t

关 键 词：低通气综合征 睡眠呼吸暂停 阻塞性 T淋巴细胞亚群 癌胚抗原 肿瘤 

分 类 号：R563[医药卫生—呼吸系统]