MCR-1介导多粘菌素耐药机制的研究进展  

ADVANCES IN MCR-1 MEDIATED MECHANISM OF POLYMYXIN RESISTANCE

作　　者：王新兴 郑常委 王巧云[4] 胡栋 王佳 翟静[1] 常维山[2] WANG Xin-xing;ZHENG Chang-wei;WANG Qiao-yun;HU Dong;WANG Jia;ZHAI Jing;CHANG Wei-shan(Taishan Medical College,Tai'an 271016,China;Shandong Agricultural University,Tai'an 271018,China;Zaozhuang Office of Qingdao Customs District,Zaozhang 277102,China;The 960th Hospital of the Chinese People's Liberation Army,Tai'an 271001,China)

机构地区：[1]泰山医学院,泰安271016 [2]山东农业大学,泰安271018 [3]青岛海关驻枣庄办事处,青岛277102 [4]中国人民解放军第960医院泰安院区,泰安271001

出　　处：《中国动物传染病学报》2018年第6期80-83,共4页Chinese Journal of Animal Infectious Diseases

基　　金：山东省农业产业技术创新体系家禽创新团队(SDA/T-11-09);双一流优势团队(515-564040);山东省重点研发计划(2015GSF19023);泰山医学院公共卫生学院课题项目(201719)

摘　　要：MCR-1主要作用是介导肠杆菌科细菌对多粘菌素产生抗药性,其基因mcr-1由1626个碱基组成,其中鸟嘌呤和胞嘧啶的含量约占了一半。根据实验推断mcr-1基因所翻译出来的是一段具有介导磷酸乙醇胺转移作用的酶,由541个氨基酸组成。菌株可携带完整的ISApl1或ISApl1片段。mcr-1是质粒上的一段基因,介导多粘菌素类药物耐药,但它并不耐受目前所有的抗生素。mcr-1耐药机制是其整合于质粒,可以随着质粒在不同细菌中水平传播,甚至可以与其他的耐药基因共同存在于单一质粒,表达后产生多种耐药机制。本文就mcr-1的发现、流行、耐药性等方面的研究进展进行简要综述。The main role of MCR-1 is to mediate polymyxin resistance in Enterobacteriaceae.mcr-1 is 1626 bp in size and the content of guanine and cytosine accounts for about half.According to previous study,mcr-1 translates an enzyme that mediates the transfer of phosphoethanolamine and consists of 541 amino acids.The host bacteria of mcr-1 can harbor the intact or truncated ISApl1 element.mcr-1 is a plasmid-carrying gene but not a new bacterial variant;it only mediates polymyxin resistance,but not to all current antibiotics.The mcr-1 can be integrated into plasmid,which mediates its horizontal transfer in different bacteria.It can even coexist with other drug resistance genes in a single plasmid,and a variety of drug resistance phenotype are generated after expression.In this paper,the discovery,prevalence and drug resistance of mcr-1 are briefly reviewed.

关 键 词：MCR-1 多粘菌素 耐药性 质粒 

分 类 号：S852.612[农业科学—基础兽医学]