猫免疫缺陷病毒宿主限制因子的研究进展  

RESEARCH PROGRESS ON HOST RESTRICTION FACTORS OF FELINE IMMUNODEFICIENCY VIRUS

作　　者：许运斌[1] 高兴红[1] 罗果[1] 王欢[1] XU Yun-bin;GAO Xing-hong;LUO Guo;WANG Huan(Guizhou Provincial College-based Key Lab of Infectious Disease&Biosafety,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医学院贵州省普通高等学校传染病与生物安全特色重点实验室,遵义563000

出　　处：《中国动物传染病学报》2018年第6期84-89,共6页Chinese Journal of Animal Infectious Diseases

基　　金：贵州省教育厅资助项目(黔教合KY字[2015]331);贵州省教育厅资助项目(黔教合KY字[2017]185);遵义医学院博士科研启动资金项(F-812)

摘　　要：猫免疫缺陷病毒(Feline immunodeficiency virus,FIV)是感染猫科动物的重要病原体,其感染的家猫是研究人免疫缺陷病毒(Human immunodeficiency virus,HIV)重要的动物模型。宿主限制因子是宿主细胞表达的通过不同途径抑制病毒感染的一系列蛋白。目前,包括HIV和FIV在内的免疫缺陷病毒宿主限制因子已成为研究热点。本文结合HIV宿主限制因子的研究现状,对FIV宿主限制因子的研究进展进行综述,从而加深对于FIV的了解,对于未来在HIV宿主限制因子抗病毒潜力评估及其药物开发方面FIV/家猫作为HIV的研究模型具有重要意义。Feline immunodeficiency virus(FIV)is an important feline pathogen.Domestic cats are used as animal models for the research on Human immunodeficiency virus(HIV).Host restriction factors include a series of proteins expressed by host cells that inhibit virus infection through different pathways.At present,discovery of the host restriction factors of immunodeficiency viruses including FIV and HIV has become a research focus.This review summarizes the research progress on host restriction factors of FIV and HIV in order to help understand virology,cat model and development of potential antiviral drugs against HIV infection.

关 键 词：猫免疫缺陷病毒 人免疫缺陷病毒 宿主限制因子 猫 

分 类 号：S852.659.3[农业科学—基础兽医学]