吉非替尼致间质性肺病死亡危险因素的Logistic回归分析  

Logistic Regression Analysis of Death Factors of Interstitial Lung Disease Induced by Gefitinib

作　　者：张士洋[1] ZHANG Shiyang(Department of Pharmaceutical,the Third People’s Hospital of Bengbu,Bengbu 233000,China)

机构地区：[1]安徽省蚌埠市第三人民医院西药科,蚌埠233000

出　　处：《药学与临床研究》2018年第6期463-465,共3页Pharmaceutical and Clinical Research

摘　　要：目的:探讨吉非替尼致间质性肺病死亡的危险因素,为安全用药提供参考。方法:检索国内外吉非替尼致间质性肺病报道文献共49篇,对部分相关因素进行单因素及多因素Logistic回归分析。结果:文献涉及62例患者,死亡21例,好转41例。单因素Logistic回归分析显示,年龄、性别、肺部疾病史、原患疾病、间质性肺病发生时间等指标可能为吉非替尼致间质性肺病死亡的危险因素;多因素Logistic回归分析显示,男性(OR=6.802,P=0.03)、有肺部疾病史(OR=10.910,P=0.047)及在14天内发生间质性肺病(OR=15.354,P=0.002)是导致吉非替尼致间质性肺病死亡的危险因素。结论:男性、肺部疾病史及早期发生间质性肺病存在死亡的风险高,应加强吉非替尼致间质性肺病监测及防治,减少致死性吉非替尼致间质性肺病的发生。Objective:To explore death factors of interstitial lung disease(ILD)induced by gefitinib and provide reference for clinical medication therapy.Methods:ILD by gefitinib reported in domestic and foreign academic journals were collected,and some relevant factors of ILD induced by gefitinib were analyzed using univariate and multivariate logistic regression analysis.Results:A total of 49 reports involving 62 patients were enrolled.Among the 62 patients,21 died and 41 improved.Univariate logistic regression analysis illustrated age,gender,history of lung disease,primary disease,time of ILD occurrence may be the death factors of ILD induced by gefitinib.Further multivariate logistic regression analysis showed that men(OR=6.802,P=0.03),history of pulmonary disease(OR=10.910,P=0.047)and ILD within 14 days(OR=15.354,P=0.002)were death factors of ILD induced by gefitinib.Conclusion:were Men with a history of pulmonary disease and early ILD are patients with higher death risks of ILD induced by gefitinib.Close monitoring should be given when using this drug to reduce the incidence of fatal ILD.

关 键 词：吉非替尼 间质性肺病 转归 危险因素 LOGISTIC回归 

分 类 号：R969.3[医药卫生—药理学] R563.13[医药卫生—药学]