FeNO水平在哮喘-慢性阻塞性肺疾病重叠治疗前后的变化及与气道炎症的关系  

Changes of FeNO level in asthma-chronic obstructive pulmonary disease before and after treatment and its relationship with airway inflammation

作　　者：刘再玲 吕晓春[1] 都丽 LIU Zai-ling;LU Xiao-chun;DU Li(Inner Mongolia Medical University Affiliated Hospital, Hohhot, Inner Mongolia 010050, China)

机构地区：[1]内蒙古医科大学附属医院,内蒙古呼和浩特010050

出　　处：《临床肺科杂志》2019年第1期50-52,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨呼出气NO(FeNO)水平在哮喘-慢性阻塞性肺疾病重叠(ACO)治疗前后的变化及其与气道炎症初筛指标间的关系。方法选择ACO患者52例为研究组,以上病例均给予ICS/LABA规范治疗,分别于治疗前后进行FeNO检测,同时采集外周血清总IgE、嗜酸性粒细胞百分比(EOS%)等指标,了解治疗前后FeNO水平、血清IgE及EOS的变化,以同期健康志愿人群(30例)为对照组;分析ACO病人FeNO水平与血清IgE、EOS等指标的关系。结果ACO病人FeNO水平与对照组比较,显著增高(P<0.05),经应用ICS/LABA规范治疗12周后,ACO病人FeNO水平较治疗前显著下降(P<0.05);Pearson相关分析表明FeNO与血清IgE浓度、嗜酸性粒细胞百分比均呈正相关(r值分别为:0.641、0.391,P<0.01)。结论ACO病人经激素+β2受体激动剂规范治疗后FeNO水平均显著降低,此变化同病人气道炎症变化具有较好相关性。Objective To explore the relationship between the changes of exo-breath NO(FeNO)level before and after treatment of asthma-chronic obstructive pulmonary disease(ACO)and the initial screening index of airway inflammation.Methods 52 patients with ACO were selected as the research group,and they were given ICS/LABA specification.The level of FeNO was detected before and after treatment,and their total IgE,FeNO and EOS%in peripheral blood were collected at the same time.The changes of serum IgE,FeNO and EOS were analyzed before and after treatment.Another 30 healthy volunteers during the same period were taken as the control group.The relationship of FeNO level with serum IgE and EOS in ACO patients was analyzed.Results The level of FeNO in the research group was significantly higher than that in the control group(P<0.05).After 12 weeks of standard application of ICS/LABA,the level of FeNO in ACO was significantly lower than before treatment(P<0.05).Pearson correlation analysis showed that FeNO had positive correlation with serum IgE concentration and eosinophil percentage(r value:0.641,0.391,P<0.01).Conclusion The level of FeNO decreases significantly after the treatment of ACO by hormone + β2 agonists,which has a good correlation with the patients'airway inflammation.

关 键 词：呼出气一氧化氮 哮喘-慢性阻塞性肺疾病重叠 气道炎症 

分 类 号：R563.9[医药卫生—呼吸系统] R562.25[医药卫生—内科学]