IVIM技术应用于评估糖尿病患者心肌微循环的初步研究  

Evaluation of myocardial microcirculation in diabetes patients by using intravoxel incoherent motion imaging: A pilot study

作　　者：李世兰 牟安娜[1] 车思雨 陈辉 宋清伟[1] 刘爱连[1] 李智勇[1] LI Shi-lan;MOU An-na;CHE Si-yu;CHEN Hui;SONG Qing-wei;LIU Ai-lian;LIZhi-yong(Dalian Medical University,Dalian 116011,China)

机构地区：[1]大连医科大学,大连116011

出　　处：《磁共振成像》2018年第12期898-903,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：辽宁省教育厅科研基金项目(编号:L2016021);辽宁省科技厅科研项目(编号:20170540235)~~

摘　　要：目的研究体素内不相干运动(intravoxel incoherent motion,IVIM)技术检测糖尿病人群的心肌微循环的差异性情况。材料与方法纳入2015年5月至2017年11月期间在大连医科大学附属第一医院3.0 T MR上行心脏IVIM成像的22例正常志愿者[男10例,平均年龄(46.22±14.26)岁]和12例糖尿病志愿者[男6例,平均年龄(58.83±14.40岁)]。采用b值(0、20、50、80、100、120、200、300、500 s/mm2)于左心室中间部短轴层面行IVIM扫描,测量IVIM的各参数[表观扩散系数(apparent diffusion coefficient,ADC)fast、ADCslow、f (fraction of ADCfast)],分析正常志愿者与糖尿病者之间心肌微循环的差异性情况。结果正常组与糖尿病组两者间左心室结构参数[左心室舒张末容积(left ventricular end-diastolic volume,LVEDV)、左心室收缩末容积(left ventricular end-systolic volume,LVESV)、左心室心肌质量(left ventricular mass,LVmass)]和功能参数[(左心室射血分数(left ventricular ejection fraction,LVEF)、每搏输出量(stroke volume,SV)、心输出量(cardiac output,CO)、心脏指数(cardiac index,CI)]差异均没有统计学意义(P>0.05)。糖尿病者的ADCfast[(0.12±0.02)×10-3 mm2/s]显著低于正常志愿者[(0.15±0.02)×10-3 mm2/s],P=0.01。结论 IVIM成像有助于评估糖尿病人群的心肌微循环情况。Objective:To preliminarily study myocardial microcirculation in diabetes patients using intravoxel incoherent motion(IVIM)imaging.Materials and Methods:22normal volunteers(10male,mean age,46.22±14.26y)and12diabetic volunteers(6male,mean age,58.83±14.40y)were enrolled in this study from May2015to November2017.All of them performed CMR-IVIM on3.0T magnetic resonance on the middle of left ventricular short axis using multi b values(0,20,50,80,100,120,200,300,500s/mm2).We measured IVIM parameters[apparent diffusion coefficient(ADC)fast,ADCslow,f(fraction of ADCfast)]and analyzed the difference of myocardial microcirculation between normal subjects and diabetes.Results:There was no significant difference in left ventricular structural[(LVEDV(left ventricular end-diastolic volume),LVESV(left ventricular end-systolic volume),LVmass]and function[LVEF(left ventricular ejection fraction),SV(stroke volume),CO(cardiac output),CI(cardiac index)]parameters between normal and diabetic subjects(P>0.05).ADCfast values in diabetic volunteers(0.12±0.02)×10^-3mm^2/s were lower than normal volunteers(0.15±0.02)×10^-3mm^2/s(P=0.01).Conclusions:It’s helpful to evaluate myocardial microcirculation in diabetic patients using IVIM imaging.

关 键 词：磁共振成像 体素内不相干运动 心肌微循环 糖尿病 

分 类 号：R445.2[医药卫生—影像医学与核医学] R587.1[医药卫生—诊断学]