弱柳珊瑚Leptogorgia rigida中次生代谢产物分离及鉴定研究(Ⅰ)  

Study on secondary metabolites from Leptogorgia rigida

作　　者：谢路凤[1] 邓芸[1] 韦霞 肖细姬[1] 于鑫 毛星鑫 张翠仙[1] XIE Lufeng;DENG Yun;MAO Xingxin;WEI Xia;XIAO Xiji;YU Xin;ZHANG Cuixian(School of Chinese Material Medica,Guangzhou University of Chinese Medicine,Guangzhou510006,China)

机构地区：[1]广州中医药大学中药学院,广东广州510006

出　　处：《广东药科大学学报》2018年第6期678-683,共6页Journal of Guangdong Pharmaceutical University

基　　金：国家自然科学基金项目(81741160);广东省科技计划项目(2015A020216017;2017A020217008);广州中医药大学"薪火计划"重点项目(XH20170110);海南大学南海海洋资源利用国家重点实验室开放课题(2016003);广东省自然基金项目(2014A030313411)

摘　　要：目的对南海弱柳珊瑚Leptogorgia rigida的次生代谢产物进行研究。方法采用硅胶柱层析和HPLC等分离手段从南海弱柳珊瑚Leptogorgia rigida的乙酸乙酯部位分离得到单体化合物,采用现代波谱技术(NMR、MS等)和物理常数对照等方法对单体化合物进行结构鉴定。结果从弱柳珊瑚甲醇提取物的乙酸乙酯部分分离得到8个化合物,分别为:柳珊瑚酸(1)、2β-羟基柳珊瑚酸(2)、4-hydroxy-2,3-dimethyl-2-nonen-4-olide (3)、9,10-二羟基-十八烷酸-十二烷基酯(4)、N-正十六碳酰基-正十八碳-4(E)-烯鞘氨醇(5)、Δ4,5(E),Δ8,9(E)-正十六碳酰胺-鞘氨醇(6)、胸腺嘧啶(7)和对羟基苯甲酸(8)。结论 8个化合物均首次从弱柳珊瑚属中得到。Objective To study the secondary metabolites from the Leptogorgia rigida of South China Sea.Methods Compounds were isolated by silica gel column chromatography and HPLC,and their structures were identified on the basis of NMR,MS,physical constants comparison and chemical methods.Results8compounds were isolated and their structures were identified as subergorgia acid(1),2-β-hydroxy-subergorgia acid(2),4-hydroxy-2,3-dimethyl-2-nonen-4-olide(3),9,10-dihydroxy octadecanoic acid dodecyl ester(4),N-palmitoyloctadecasphinga-4(E)-ene(5),Δ4,5(E),Δ8,9(E)-N-hexadecamide-sphingol(6),thymine(7),and4-hydroxy benzonic acid(8).Conclusion All the compounds were firstly isolated from Leptogorgia rigida.

关 键 词：弱柳珊瑚 次生代谢产物 分离 倍半萜 结构鉴定 

分 类 号：R284.2[医药卫生—中药学]