miR-17与冠心病患者冠状动脉病变程度、侧支循环形成及血清Ox-LDL、25(OH)D3的关系  

Association between miR-17 and lesion severity,formation of collateral circulation and serum ox-LDL and 25(OH)D3 in patients with coronary heart disease

作　　者：范迎春[1] 卓著 李潇 赵立飞 卢静海[5] FAN Yingchun;ZUO Zhu;LI Xiao;ZHAO Lifei;LU Jinghai(Department of Laboratory,Shengli Hospital of Shengli Oilfield,dongying 257055,Ch)

机构地区：[1]胜利油田胜利医院检验科,山东 临沂 276023 [2]临沂市第三人民医院心血管内科,山东 临沂 276023 [3]临沂市第三人民医院内三科,山东 临沂 276023 [4]临沂市经济开发区人民医院检验科,山东 临沂 276000 [5]胜利油田胜利医院心内科,山东 临沂 276000

出　　处：《实用医学杂志》2018年第23期3924-3928,共5页The Journal of Practical Medicine

基　　金：2018年山东省石油管理局科技进步计划(编号:GKY1804).

摘　　要：目的研究miR-17与冠心病患者冠状动脉病变程度、侧支循环形成及血清氧化修饰低密度脂蛋白(Ox-LDL)、25羟基维生素D3[25(OH)D3]的关系。方法选择2014年3月至2017年10月在胜利油田胜利医院心内科确诊的157例稳定性冠心病患者作为病例组,100例健康者为对照组。根据SYNTAX评分将病例组分为冠脉病变重度组44例、中度组61例和轻度组52例,根据Rentrop将病例组分为侧支循环良好组82例,不良组75例。分别检测受试者血清miR-17、25(OH)D3、Ox-LDL水平,分析病例组血清miR-17与SYNTAX评分、Rentrop分级及Ox-LDL、25(OH)D3水平的关系。结果病例组血清miR-17、Ox-LDL水平显著高于对照组,冠脉病变重度组和中度组显著高于轻度组,重度组显著高于中度组,冠脉侧支循环不良组显著高于良好组;病例组血清25(OH)D3水平显著低于对照组,冠脉病变重度组和中度组显著低于轻度组,重度组显著低于中度组,冠脉侧支循环不良组显著低于良好组;病例组血清miR-17与SYNTAX评分、Ox-LDL分别呈显著正相关关系(r=0.653、0.711,P=0.000、0.000),与Rentrop分级、25(OH)D3分别呈显著负相关关系(r=-0.624、-0.735,P=0.000、0.000)。结论冠心病患者血清miR-17水平显著升高,与患者冠脉病变程度、侧支循环形成及血清Ox-LDL、25(OH)D3水平密切相关,可能在冠脉病变发生发展中发挥重要作用。Objective To discuss the association between miR-17 and lesion severity,formation of collat-eral circulation and serum oxidized low density lipoprotein(Ox-LDL)and 25 hydroxyl vitamin D3[25(OH)D3]in patients with coronary heart disease.Methods from March 2014 to October 2017,157 patients with confirmed stable coronary heart disease in the Department of Cardiology were enrolled in case group,and 100 healthy subjects were recruited in control group.According to the SYNTAX score,44 cases were assigned to severe group,61 cases to moderate group and 52 cases to mild group;according to Rentrop classification,82 cases were assigned to good collateral circulation group and 75 cases to bad group.The levels of serum miR-17,25(OH)D3 and Ox-LDL were detected respectively.The relationships between serum miR-17 with SYNTAX score,Rentrop classifi-cation,Ox-LDL and 25(OH)D3 levels in case group were analyzed.Results Serum miR-17 and Ox-LDL levels in case group were significantly higher than those in control group,the severe coronary artery disease group and moderate group were significantly higher than mild group,the severe group was significantly higher than the moder-ate group,the bad coronary collateral circulation group was significantly higher than the good group;serum 25(OH)D3 level in case group was significantly lower than that in control group,the severe coronary artery disease group and moderate group were significantly lower than mild group,the severe group was significantly lower than the moderate group,the bad coronary collateral circulation group was significantly higher than the good group;there were significant positive correlations between serum miR-17 with SYNTAX score and Ox-LDL in case group(r=0.653,0.711,P=0.000,0.000),there were significant negative correlations between serum miR-17 with Rentrop classification and 25(OH)D3(r=-0.624,-0.735,P=0.000,0.000).Conclusions The levels of se-rum miR-17 in patients with coronary heart disease were significantly increased,which is closely related to lesion severity of c

关 键 词：miR-17 冠脉病变程度 侧支循环形成 氧化修饰低密度脂蛋白 25羟基维生素D3 

分 类 号：R541.4[医药卫生—心血管疾病]