莫西沙星对社区获得性肺炎患者药代动力学及凝血功能的影响  

Effect of Moxifloxacin on Pharmacokinetics and Coagulation Function in Community Patients with Acquired pneumonia

作　　者：戴薇[1] 戴颖[1] DAI Wei;DAI Ying(Department of Pharmacy, Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing 210028, Jiangsu, China)

机构地区：[1]江苏省中西医结合医院药学部,江苏南京210028

出　　处：《贵州医科大学学报》2018年第12期1462-1465,共4页Journal of Guizhou Medical University

摘　　要：目的:研究莫西沙星对社区获得性肺炎患者的药代动力学及凝血功能的影响。方法:社区获得性肺炎患者80例随机均分为莫西沙星组和左氧氟沙星组,分别静脉给予相应药物;检测两组患者治疗后血清和肺泡灌洗液中的药物浓度、药物在肺组织中的穿透率及在血清中的清除半衰期,比较治疗前后两组患者纤维蛋白原(FIB)、抗凝血酶-Ⅲ(AT-Ⅲ)、血小板计数及凝血酶时间,观察治疗效果及不良反应。结果:莫西沙星组患者血清和肺泡灌洗液中的药物浓度高于左氧氟沙星组,药物在肺组织中的穿透率高于左氧氟沙星组,血浆清除半衰期大于左氧氟沙星组,差异具有统计学意义(P <0. 05);治疗后两组患者FIB水平低于治疗前,AT-Ⅲ水平、血小板计数和凝血酶时间均高于治疗前,差异具有统计学意义(P <0. 05);治疗后,莫西沙星组患者FIB水平低于左氧氟沙星组,莫西沙星组AT-Ⅲ水平、血小板计数和凝血酶时间均高于左氧氟沙星组,差异具有统计学意义(P <0. 05);莫西沙星组临床总有效率高于左氧氟沙星组,不良反应发生率低于左氧氟沙星组,差异具有统计学意义(P <0. 05)。结论:莫西沙星在治疗社区获得性肺炎时的药代动力学稳定,有助于患者凝血功能的改善。Objective:To investigate the effects of moxifloxacin on pharmacokinetics and coagulation function in community patients with acquired pneumonia.Methods:Eighty community patients with acquired pneumonia were randomly divided into moxifloxacin group and levofloxacin group,respectively,and the corresponding drugs were administered intravenously.The drug concentration and half-life were measured in the serum and alveolar lavage fluid after treatment.The drug penetrability in the lung tissue is also examined.The fibrinogen(FIB),anti-thrombin-Ⅲ(AT-Ⅲ),platelet count and thrombin time were measured before and after drug treatment.The therapeutic effect and adverse reactions were observed.Results:The drug penetration rate in the lung tissue and the drug concentrations in serum and alveolar lavage fluid were higher in moxifloxacin group than in the levofloxacin group(P<0.05and P<0.05,respectively).The plasma half-life was longer in moxifloxacin group than that in levofloxacin group(P<0.05);the FIB levels were lower than those before treatment(P<0.05),whereas the AT-III level,platelet count and thrombin time were higher than those before treatment(P<0.05);after treatment,the FIB levels,platelet count and thrombin time in moxifloxacin group were lower than those in levofloxacin group(P<0.05),whereas the level of AT-III in the moxifloxacin group was higher than that in the levofloxacin group(P<0.05).The total clinical efficient rate in moxifloxacin group was significantly higher than that in levofloxacin group,whereas the incidence of adverse reactions was lower than that in the levofloxacin group(P<0.05).Conclusion:The pharmacokinetics of moxifloxacin in the treatment of community patients with acquired pneumonia is very stable and helpful to the improve patient coagulation function.

关 键 词：莫西沙星 左氧氟沙星 社区获得性肺炎 药代动力学 凝血功能 

分 类 号：R563.1[医药卫生—呼吸系统]