胰岛素抵抗对葡萄糖耐量受损患者冠状动脉侧支循环的影响  

Effect of insulin resistance on coronary collateral circulation in patients with impaired glucose tolerance

作　　者：陈武奇[1] CHEN Wu-qi(Guangdong Provincial Second People’s Hospital,Guangzhou 510317,China)

机构地区：[1]广东省第二人民医院,广东广州510317

出　　处：《广东医科大学学报》2018年第5期490-492,496,共4页Journal of Guangdong Medical University

摘　　要：目的了解胰岛素抵抗对葡萄糖耐量(GT)受损患者冠状动脉侧支循环(CCC)的影响。方法 90例GT受损者及50例GT正常者作冠状动脉造影,用Rentrop法评价CCC情况,Logistic回归分析冠状动脉狭窄(CAS)或CCC与血糖、糖化血红蛋白、胰岛素抵抗指数相关性。结果 Logistic回归分析显示血糖、糖化血红蛋白、胰岛素抵抗指数与CCC呈负相关,但与CAS呈正相关;空腹胰岛素与CCC呈正相关,但与CAS呈负相关(均P<0.01)。结论 GT受损患者胰岛素抵抗可能促进CAS并影响CCC形成。Objective To study the effect of insulin resistance(IR)on coronary collateral circulation(CCC)in patients with impaired glucose tolerance(GT).Methods Ninety patients with impaired GT and 50 subjects with normal GT underwent coronary angiography.CCC was evaluated using Rentrop classification.The correlations between coronary artery stenosis(CAS)or CCC and blood glucose,glycosylated hemoglobin and IR were assessed by Logistic regression analysis.Results Logistic regression analysis showed that blood glucose,glycosylated hemoglobin and IR were negatively correlated with CCC but positively with CAS,while fasting insulin was positively related to CCC but negatively to CAS.Conclusion IR might enhance CAS but reduce CCC in patients with impaired GT.

关 键 词：葡萄糖耐量 冠状动脉侧支循环 胰岛素抵抗 

分 类 号：R543.3[医药卫生—心血管疾病]