TGF-β1表达对胃癌手术患者预后的影响  

Effect of expression of TGF-β1 in prognosis of patients with resected gastric cancer

作　　者：党海珍[1] 姜忠华[1] 刘子新 焦顺昌[2] Dang Haizhen;Jiang Zhonghua;Liu Zixin(Department of Senior Cadre,PLA 401 Hospital,Qingdao 266071,China)

机构地区：[1]解放军第401医院干部三科,青岛266071 [2]解放军总医院第一医学中心肿瘤中心

出　　处：《中华保健医学杂志》2018年第6期467-470,共4页Chinese Journal of Health Care and Medicine

摘　　要：目的总结回顾手术切除Ⅰ～Ⅲ期胃癌的临床特点,研究胃癌、胃癌旁、胃正常组织TGF-β1的表达,探索能预测胃癌预后的临床及分子特征,寻找能够早期诊断及预测胃癌术后复发风险的分子标记物。方法回顾性分析2010年1月～2011年6月在解放军总医院第一医学中心行手术治疗Ⅰ～Ⅲ期胃癌患者41例,以免疫组织化学Envision二步法检测TGF-β1在胃癌、胃癌旁、胃正常组织的表达,探讨各组病例的临床特征、病理特点及与术后无病生存期(DFS)的关系。结果 TGF-β1在胃癌组织、胃癌旁组织、胃正常组织均有阳性表达,表达率分别为70.73%、34.15%、51.22%。TGF-β1在不同临床特征胃癌组织的阳性表达率:无饮酒史患者高于有饮酒史患者(82.8%vs 41.7%),肿瘤T分期T3～4期高于T1～2期(81.3%vs 33.3%),差异均有统计学意义(P <0.05);TGF-β1在胃癌组织阳性表达DFS生存率低于阴性表达,差异有统计学意义(37.93%与50%,P <0.05)。结论 TGF-β1在胃正常组织阳性表达有助于诊断胃癌,在胃癌组织阳性表达与肿瘤分期有关,阳性表达者DFS生存率降低,预后不良。Objective To summarize the clinical features of surgical resection of gastric cancer(GC)in stageⅠ~Ⅲ,to investigate the expression of transforming growth factor-β1(TGF-β1)in cancer mass,paracancerous and normal gastric tissues,to explore the clinical and molecular characteristics that could predict the prognosis of gastric cancer,and to search for molecular markers that could diagnose and predict the risk of postoperative recurrence of gastric cancer.Methods A retrospective analysis of 41 cases of surgical treatment of stage I-III gastric cancer in the General Hospital of PLA from January 2010 to June 2011.Immunohistochemical Envision two-step method was used to detect the expression of TGF-β1 in cancer mass,paracancerous and normal gastric tissues,and to investigate the clinical features,pathological features and relationship between disease-free survivals(DFS)in each group.Results TGF-β1 was positively expressed in cancer mass,paracancerous and normal gastric tissues,and the expression rates were 70.73%,34.15%and 51.22%,respectively;Positive expression rate of TGF-β1 in gastric cancer tissues with different clinical features:Patients with no drinking history were higher than those with drinking history(82.8%vs 41.7%),Tumor T stage T3-4 was higher than T1-2(81.3%vs 33.3%),the difference was statistically significant(P<0.05,P<0.01);The survival rate of TGF-β1 positively expressed in gastric cancer tissues was lower than that of negative expression,which was 37.93%vs 50%(P<0.05).Conclusion The positive expression of TGF-β1 in normal gastric tissue contributes to the diagnosis of gastric cancer.The positive expression of TGF-β1 in gastric cancer is related to tumor stage.The positive rate of DFS is lower and the prognosis is unfavorable.

关 键 词：胃癌 术后 转化生长因子-Β1 预后 

分 类 号：R735.2[医药卫生—肿瘤]