1例HIV-1/HBV共感染复杂病例抗病毒治疗100周期间NK细胞、CD4^+T细胞及相关指标的变化  

Changes of natural killer cells, CD4^+T cells and clinical indexes in one complicated case of HIV-1/HBV co-infection during 100-week antiretroviral therapy

作　　者：金磊 常文仙 黄磊 李静 张纪元 王福生 JIN Lei;CHANG Wen-xian;HUANG Lei;LI Jing;ZHANG JI-yuan;WANG Fu-sheng(Treatment and Research Center for Infectious Diseases,the Fifth Medical Center of Chinese PLA General Hospital,Beijing100039,China)

机构地区：[1]中国人民解放军总医院第五医学中心感染性疾病诊疗与研究中心,北京100039 [2]南京第二人民医院肝病科,210003

出　　处：《传染病信息》2018年第6期571-574,共4页Infectious Disease Information

基　　金："十三五"国家传染病重大专项(2018ZX10302104-002)

摘　　要：HBV合并HIV-1感染时,HIV-1感染会增加慢性HBV感染相关的肝炎、肝硬化和终末期肝病的风险。本文对1例HIV-1/HBV共感染病例进行抗反转录病毒治疗(antiretroviral therapy, ART)并随访100周,分析了ART对患者乙型肝炎相关病毒学及肝功能指标的影响,同时分析了NK细胞数量的动态变化,并结合相关文献进行回顾分析,为临床防治免疫导致的HIV-1/HBV共感染患者肝脏损伤提供借鉴。HIV-1co-infection can increase the risks of HBV infection-related hepatitis,hepatic cirrhosis and end-stage liver diseases.This paper reported one HIV-1/HBV co-infected patient undergoing antiretroviral therapy(ART)and100-week follow-ups,analyzed the effect of ART on indexes for hepatitis B related virology and liver function,as well as dynamic changes of natural killer cell counts.We further retrospectively analyzed relevant literatures,and provided a reference for clinical prevention and treatment of liver damage in HIV-1/HBV co-infected patients.

关 键 词：人类免疫缺陷病毒 乙型肝炎病毒 自然杀伤细胞 共感染 肝损伤 乙型肝炎表面抗原 

分 类 号：R512.91[医药卫生—内科学] R512.62[医药卫生—临床医学]