顺式-二氯·氨·异丙胺合铂(Ⅱ)的合成及抗肿瘤活性  

Synthesis,Structure and Characterization of CIS-Dichloro-ammonia,Isopropyl Amine Platinum(Ⅱ)

作　　者：贝玉祥 闫玉鑫[2] 丛艳伟 张琪 何键 普绍平 Bei Yuxiang;Yan Yuxin;Cong Yanwei;Zhang Qi;He Jian;Pu Shaoping(Kunming Guiyan Pharmaceutical Co.,Ltd,Kun ming,650106,Yun nan,China;Yunnan Normal University Vocational and Technical Education College,Kunming,650100,China)

机构地区：[1]昆明贵研药业有限公司,云南昆明650106 [2]云南师范大学职业技术教育学院,云南昆明650000

出　　处：《云南化工》2018年第10期144-145,共2页Yunnan Chemical Technology

摘　　要：以三氯氨铂酸钾为原料,采用水解法合成顺式-二氯·氨基·异丙胺基合铂,确定了最佳合成路线及工艺参数,并通过元素分析、红外光谱、核磁共振谱和质谱对结构进行了表征,通过MTT评价了配合物的体外抗肿瘤活性。In Potassium trichloroammine palatinate(Ⅱ)as the starting material,cis-dichloro-ammonia,isopropylamine platinum(Ⅱ)was synthesized by hydrolysis and then the best process parameters were determined by experiment.Elemental analysis,infrared and nuclear magnetic resonance were used to characterize its chemical structure,The in vintro antitumor activity was evaluated by MTT.

关 键 词：铂类抗肿瘤药物 合成 结构 抗肿瘤活性 

分 类 号：TQ138.26[化学工程—无机化工]