苯并恶唑型Pd(Ⅱ)配合物与Ct-DNA的相互作用模式研究  

The Study of Interaction Model between Benzoxazole Pd(Ⅱ) Complex and Ct-DNA

作　　者：张腾飞 李立军[1] Zhang Tengfei;Li Lijun(College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China)

机构地区：[1]河北大学化学与环境科学学院,河北保定071002

出　　处：《广东化工》2018年第24期3-4,共2页Guangdong Chemical Industry

基　　金：河北省自然科学基金(No.B 2014201174)

摘　　要：本文以5-氯水杨醛与邻氨基苯酚反应得到苯并恶唑配体,并将得到的苯并恶唑配体与氯化钯反应得到相应的单核钯配合物。运用红外光谱对钯配合物进行了表征,红外光谱表明羟基氧、恶唑环上的氮原子与金属离子钯(Ⅱ)发生了配位。利用紫外可见光谱、圆二色光谱等研究了配合物与小牛胸腺DNA的相互作用模式。结果表明,配合物与DNA的作用模式为插入模式。In this paper,benzoxazole ligand was synthesized by the reaction of5-chloro-salicylaldehyde with o-aminophenol.The corresponding palladium complexes were obtained by the reaction of benzoxazole ligands with palladium chloride.The complexes of palladium were characterized by infrared spectroscopy.The results showed that the nitrogen atom on the oxazole ring and hydroxyl oxygen coordinated with the palladium(Ⅱ).The interaction modes of the complexes with calf thymus DNA were studied by UV-Vis and circular dichroism spectra.The results show that the mode of interaction of the complex with DNA is an intercalative mode.

关 键 词：钯(Ⅱ)金属配合物 苯并恶唑配体 钯(Ⅱ)与DNA作用模式 

分 类 号：TQ[化学工程]