抗真菌药物及其耐药机制研究进展  

Progress in Antifungal Drugs and Drug-Resistance Mechanisms

作　　者：王光裕 杨英 车宝泉[2] 李文东[2] 王升启 WANG Guang-Yu;YANG Ying;CHE Bao-Quan;LI Wen-Dong;WANG Sheng-Qi(Beijing Institute of Radiation Medicine,Beijing 100850;Beijing Institute for Drug Control,Beijing 100035,China)

机构地区：[1]军事医学研究院辐射医学研究所,北京100850 [2]北京市药品检验所,北京100035

出　　处：《生物技术通讯》2018年第6期856-860,865,共6页Letters in Biotechnology

基　　金：中国工程院咨询研究项目(2017-XY-35);艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2018ZX10712001;2018ZX10101003)

摘　　要：侵袭性真菌感染,由于其高发病率和死亡率,对人类健康造成严重威胁。针对侵袭性真菌自身生长繁殖的生物学过程,人们开发了不同的抗真菌药物对其进行阻断、干扰,从而达到杀菌抑菌的目的。我们简要介绍临床常见抗真菌药物的种类、作用机制、耐药机制以及应对耐药的方法。Invasive fungal infections pose a serious threat to human health due to their high morbidity and mortality.To achieve the purpose of killing or inhibition,various antifungal drugs have been developed to block and interfere with the biological process of invasive fungi self-growth and reproduction.This review mainly focused on common clinical antifungal drugs regarding the classification and action mechanisms,drug resistance mechanisms and countermeasures.

关 键 词：侵袭性真菌 耐药机制 抗真菌药物 耳念珠菌 

分 类 号：R978.5[医药卫生—药品]