台州市大气PM2.5对成年男性精液质量的影响  

Atmospheric PM2.5 exposure on semen quality in adult men in Taizhou

作　　者：胡富宇 郭婷婷 朱珊珊[1] 花静 刘依萍 张黎明[1] 杨莹莹 HU Fu-yu;GUO Ting-ting;ZHU Shan-shan;HUA Jing;LIU Yi-ping;ZHANG Li-ming;YANG Ying-ying(Taizhou Central Hospital,Taizhou,Zhejiang 318000,China)

机构地区：[1]台州市中心医院,浙江台州318000 [2]同济大学附属第一妇婴保健院

出　　处：《预防医学》2019年第1期20-22,27,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：上海市科学技术委员会科研项目(18140903100);上海市卫生和计划生育委员会青年基金(20174Y0010)

摘　　要：目的了解大气PM2.5暴露对成年男性精液质量的影响。方法 收集2014年8月—2017年12月在台州市中心医院孕前门诊体检者的精液检测数据,排除无精症、生殖相关疾病患者;收集当地同期大气污染物(PM2.5,PM10,SO2,NO2,O3和CO)监测数据,计算研究对象精液检测前90天的大气污染物日均暴露浓度;采用Logistic回归模型分析精液检测前90天PM2.5暴露对男性精液质量的影响。结果 共纳入3456名成年男性,精子总数M(QR)为161.00(122.00)×10^6/1次射精,合格率为94.40%;精子密度M(QR)为22.20(18.80)×10^6/mL,合格率为69.50%;精子活率M(QR)为55.30%(23.37%),合格率为44.10%。精液检测前90天的PM2.5日均浓度M(QR)为37.82(12.33)μg/m^3。Logistic回归分析结果显示,精液检测前90天的PM2.5日均暴露浓度每升高12.33μg/m^3,精子密度、精子活力和精子活率不合格的风险OR值分别为1.236(95%CI:1.041~1.466)、1.493(95%CI:1.260~1.770)和1.462(95%CI:1.246~1.715)。结论 PM2.5暴露浓度升高可能导致成年男性的精子密度、精子活力和精子活率降低。Objective To explore the effects of ambient fine particulate matter(PM2.5)exposure on semen quality in healthy adult men.Methods The semen quality data were collected from the pre-pregnancy check outpatient of Taizhou Central Hospital from August2014to December2017,excluding the patients with any disease of reproductive system.The data of daily pollutant concentration of this area during the same period were also collected to estimate the exposures of PM2.5,PM10,SO2,NO2,O3and CO during90days before each semen examination.Logistic regression model was applied to estimate the association between PM2.5exposure and semen quality.Results A total of3456healthy adult men were included in this study.The median(interquartile range)of the total sperm count of the3456subjects was161.00(122.00)×10^6,and94.40%of the subjects could reach the lower reference limit for sperm count.The median(interquartile range)of the sperm concentration was22.20(18.80)×10^6/mL,and69.50%of the subjects were qualified.The median(interquartile range)of the sperm vitality was55.30%(23.37%),and44.10%of the subjects were qualified.The median(interquartile range)of daily average concentration of PM2.5at0-90days before semen examination was37.82(12.33)μg/m^3.The results of multivariate logistic regression model showed that,with each12.33μg/m^3 increase of PM2.5exposures at0-90days before semen examination,the odds ratios of unqualified sperm concentration,sperm motility and sperm vitality were1.236(95%CI:1.041-1.466),1.493(95%CI:1.260-1.770)and1.462(95%CI:1.246-1.715),respectively.Conclusion The results suggested that high concentration of ambient PM2.5exposure during the sperm development period negatively affects sperm concentration,sperm motility and sperm vitality.

关 键 词：PM2.5 精液质量 精子 大气污染物 

分 类 号：R122.7[医药卫生—环境卫生学] R698.2[医药卫生—公共卫生与预防医学]