小剂量多巴胺治疗窒息后肾损害临床疗效及对新生儿呼气峰流速值、心率、平均动脉压水平影响  

The effect of low dose dopamine on the clinical efficacy of neonatal after asphyxiation and the influence of PEF,HR,MAP level

作　　者：王博雄 张子友[1] 吉张艳 WANG Boxiong;ZHANG Ziyou;JI Zhangyan(Department of Pediatrics, Dongfang Municipal People's Hospital in Hainan Provinve,Dongfang 572600)

机构地区：[1]海南省东方市人民医院儿科,东方572600

出　　处：《陕西医学杂志》2019年第1期105-107,共3页Shaanxi Medical Journal

摘　　要：目的:研究小剂量多巴胺对窒息后肾损害新生儿的临床疗效及对呼气峰流速值(PET)、心率(HR)、平均动脉压(MAP)水平的影响。方法:选取息后肾损害新生儿120例。根据随机数字表法均分成研究组与对照组,每组60例。对照组患儿予以常规综合治疗,研究组则在常规综合治疗的基础上予以小剂量多巴胺治疗。比较两组临床疗效,治疗后PEF、HR、MAP水平,治疗前后血肌酐与尿素氮水平,脏器受损情况。结果:研究组治疗总有效率为95.00%(57/60),明显高于对照组的80.00%(48/60),差异有统计学意义(P<0.05)。治疗后研究组PEF、HR、MAP水平分别为(6.8±1.2)L/min、(76.5±11.8)次/min、(91.0±10.4)mmHg,均明显高于对照组的(5.9±1.0)L/min、(68.7±12.3)次/min、(82.2±11.5)mmHg,差异均有统计学意义(P<0.05)。治疗后研究组肌酐与尿素氮水平分别为(67.2±14.8)mmol/L、(5.2±1.2)μmol/L,均明显低于对照组的(87.4±18.2)mmol/L、(8.4±2.1)μmol/L,差异均有统计学意义(P<0.05)。治疗后研究组肾功能障碍发生率为13.33%(8/60),明显低于对照组的51.67%(31/60),差异有统计学意义(P<0.05)。结论:小剂量多巴胺治疗窒息后肾损害新生儿的临床疗效显著,可有效改善患儿PEF、HR、MAP水平,有利于改善患儿肾功能,具有较高的临床价值。Objective:To study the small dose dopamine clinical curative effect of renal damage after asphyxia newborn and the expiratory peak velocity value(PET),heart rate(HR),mean arterial pressure(MAP)level.Methods:120 cases of neonatal injury after asphyxiation were selected.The random digital table method was divided into the study group and the control group,60 cases in each group.The children in the control group received routine comprehensive treatment,and the study group received a small dose of dopamine treatment on the basis of routine comprehensive treatment.The clinical efficacy of the two groups was compared.After treatment,PEF,HR and MAP were treated,and the blood creatinine and urea nitrogen levels were compared before and after treatment.Results:The total effective rate was95.00%(57/60),which was significantly higher than80.00%(48/60)in the control group,and the difference was statistically significant(P<0.05).Team PEF,HR and MAP level after treatment respectively was(6.8±1.2)L/min,(76.5±11.8)times/min,(91.0±10.4)mmHg,which was significantly higher than that of control group(5.9±1.0)L/min,(68.7±12.3)times/min,(82.2±11.5)mmHg,differences were statistically significant(all P<0.05).Team of creatinine and urea nitrogen levels after treatment respectively was(67.2±14.8)mmol/L,(5.2±1.2)μmol/L,which were significantly lower than in the control group(87.4±18.2)mmol/L,(8.4±2.1)μmol/L,the differences were statistically significant(all P<0.05).After treatment,the incidence of renal dysfunction was 13.33%(8/60),was significantly lower than the control group of 51.67%(31/60),and the difference was statistically significant(P<0.05).Conclusion:Small dose of dopamine in the treatment of renal damage after asphyxia newborn curative effect significantly,can effectively improve children PEF,HR,MAP,and can help children improve renal function,has high clinical value.

关 键 词：窒息后肾损害 新生儿 呼气峰流速值 心率 平均动脉压 多巴胺 

分 类 号：R722.19[医药卫生—儿科]