妊娠期高血压患者尿蛋白和血常规水平分析及对妊娠结局的影响  

Analysis of urinary protein and blood routine levels in patients with hypertensive disorder during pregnancy and its effect on pregnancy outcome

作　　者：蒋永悟 JIANG Yongwu(Clinical Laboratory of Ankang Maternal and Child Health Hospital,Ankang 725000)

机构地区：[1]陕西省安康市妇幼保健院检验科,安康725000

出　　处：《陕西医学杂志》2019年第1期128-130,共3页Shaanxi Medical Journal

基　　金：陕西省科技攻关项目(2009K16-02)

摘　　要：目的:研究妊娠期高血压患者尿蛋白和血常规水平分析及对妊娠结局的影响。方法:选取收治的妊娠期高血压疾病患者159例,其中妊娠期高血压组55例,轻度子痫前期组64例,重度子痫前期组40例,比较并分析三组患者的尿蛋白阳性率、BUN和Cr含量,血常规和凝血功能,包括血红蛋白(Hb)、血小板(PLT)、红细胞压积(HCT)、外周血红细胞(RBC)、纤维蛋白原(FIB)和凝血酶原时间(PT),以及不良妊娠结局的发生率,包括早产,低体重儿,子痫,胎盘早剥,胎儿生长受限,新生儿窒息,胎儿窘迫。结果:三组之间尿蛋白阳性率间差异有统计学意义(P<0.05),重度子痫前期尿蛋白阳性率显著高于妊娠期高血压组和轻度子痫前期组(P<0.05)。重度子痫前期组BUN和Cr显著高于妊娠期高血压组(P<0.05)。三组之间PLT、HCT和RBC水平差异有统计学意义(P<0.05),重度子痫前期组PLT和RBC水平显著低于妊娠期高血压组和轻度子痫前期组(P<0.05)。重度子痫前期组FIB和PT显著低于妊娠期高血压组(P<0.05)。三组之间早产、胎儿生长受限和胎盘早剥的发生率差异有统计学意义(P<0.05)。结论:对妊娠期高血压疾病患者应定期进行尿蛋白和血常规水平的分析,以便尽早进行诊断和治疗,减少不良妊娠结局的发生。Objective:To analyze the urinary protein and blood routine levels in patients with hypertensive disorder during pregnancy and its effect on pregnancy outcome.Methods:159 patients with hypertensive disorder complicating pregnancy were enrolled in our hospital,including 55 patients with gestational hypertension,64patients with mild preeclampsia,and40patients with severe preeclampsia.Compare and analyze urine protein,BUN and Cr levels,blood routine and coagulation functions,including Hb,PLT,HCT,RBC,FIB and PT,and adverse pregnancy outcomes,including preterm birth,low birth weight,eclampsia,Placental abruption,fetal growth restriction,neonatal asphyxia,fetal distress.Results:The urine protein ratio of the three groups was significantly different(P<0.05).The urine protein ratio in severe preeclampsia was significantly higher than that in the pregnant hypertensive group and mild preeclampsia group(P<0.05).BUN and Cr in the severe preeclampsia group were significantly higher than those in the hypertensive group(P<0.05).The PLT,HCT and RBC levels were significantly different between the three groups(P<0.05).The PLT and RBC levels in the severe preeclampsia group were significantly lower than those in the hypertensive group and the mild preeclampsia group(P<0.05).The FIB and PT in the severe preeclampsia group were significantly lower than those in the hypertensive group(P<0.05).The incidence of preterm birth,fetal growth restriction and placental abruption between the three groups was significantly different(P<0.05).Conclusion:Patients with hypertensive disorder complicating pregnancy should be regularly analyzed for urinary protein and blood levels,in order to diagnose and treat as early as possible to reduce the incidence of adverse pregnancy outcomes.

关 键 词：妊娠期高血压 尿蛋白 血常规 妊娠结局 对比研究 

分 类 号：R714.2[医药卫生—妇产科学]