儿童单核细胞增生李斯特菌脑膜炎临床研究  

Clinical Study of Children with Listeria Monocytogenes Meningitis

作　　者：羡一心[1] 陈国洪 王莉[1] 刘凯[1] CHEN Guo-hong;WANG Li;LIU Kai(Affiliated children's hospital of Zhengzhou university/Children's hospital of henan province/Children's hospital of zhengzhou,zhengzhou,Henan,450000,China)

机构地区：[1]郑州大学附属儿童医院河南省儿童医院郑州儿童医院,河南郑州450000

出　　处：《临床研究》2019年第1期7-9,共3页Clinical Research

摘　　要：目的总结儿童单核细胞增生李斯特菌(LM)脑膜炎的临床特征,提高对该病的认识。方法回顾性分析10例LM脑膜炎患儿的临床特点、治疗方案。结果 LM脑膜炎多发生于免疫功能受损的人,通过摄入受污染的食物获得感染,经典的临床症状为发热、头痛、颈强直和精神状态改变,治疗上三代头孢不敏感,有效的抗生素为氨苄青霉素、美罗培南、复方新诺明。结论对于脑膜炎患者,经验性传统用药疗效不佳时,应考虑LM脑膜炎可能,联合有效覆盖李斯特菌的抗生素。Objective To better understand the clinical characteristics in children with listeria monocytogenes(LM)meningitis.Methods The clinical features,therapeutic regimen of 10 children with LM meningitis were summarized by a retrospective study.Results LM meningitis occurs almost in immunosuppressed patients through contaminated food.The classic clinical symptoms are fever,neck stiffness,and altered mental status.LM is susceptible to ampicillin,meropenem,TMP/SMX,which is not susceptible to third-generation cephalosporins.Conclusions Empiric antibiotics covering Listeria should be considered when LM meningitis is suspected among patients of meningitis with poor curative effects.

关 键 词：脑膜炎 单核细胞增生李斯特菌 儿童 临床症状 治疗 

分 类 号：R515.2[医药卫生—内科学]