TGF-β、CRP、UA和D-dimer等血清标志物对主动脉夹层诊断及预后评估的价值  被引量:6

The Values of Serum Markers TGF-β,CRP,UA and D-dimer in the Diagnosis and Prognosis of Aortic Dissection

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作  者:邹振武 邓艳斌 李德忠 谭金波 ZOU Zhen-wu;DENG Yan-bin;LI De-zhong;TAN Jin-bo(Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi 445000,China)

机构地区:[1]恩施土家族苗族自治州中心医院,湖北恩施445000

出  处:《标记免疫分析与临床》2018年第12期1853-1856,1876,共5页Labeled Immunoassays and Clinical Medicine

摘  要:目的探讨转化生长因子(TGF-β)、C反应蛋白(CRP)、尿酸(UA)、D-二聚体(D-dimer)等血清标志物对主动脉夹层(AD)的诊断及预后价值。方法选取2014年2月至2017年2月在本院治疗的AD患者60例(AD组),选择同期非AD患者100例作为对照组,检测两组患者血清TGF-β、CRP、UA、D-dimer和肌钙蛋白Ⅰ(cTNI),同时比较不同预后患者各指标差异。结果 AD组患者TGF-β、CRP、D-dimer、UA和cTNI分别为34.22±4.12ng/mL、14.50±2.01mg/mL、870.04±60.03ng/mL、385.52±32.08μmol/L和2.41±0. 15ng/mL,明显高于对照组(P <0.05);死亡组患者TGF-β、CRP、Ddimer和cTNI分别为38.11±3.27ng/mL、16.40±2. 08mg/L、902.12±40.04ng/mL和2.61±0. 30ng/mL,明显高于存活组(P <0.05);TGF-β、CRP、D-dimer、UA和cTNI在诊断AD中均有一定的价值,其中TGF-β诊断AD的ROC曲线下面积为0.901,截断值为30.12ng/mL时,灵敏度和特异性分别为80.40%和84.44%;TGF-β、CRP、D-dimer在判断AD患者预后方面有一定价值,其中D-dier判断AD患者死亡的ROC曲线下面积0.782,截断值为890.62ng/mL时,灵敏度和特异性分别为85.56%和80.05%。结论 TGF-β、CRP、D-dimer等血清标志物在AD诊断及预后判断中有一定的应用价值,其中TGF-β诊断AD的效能较好,而D-dimer判断预后效能较好。Objective To investigate transforming growth factorβ(TGF-β),C reactive protein(CRP),uric acid(UA),D-dimer(D-dimer)and other serum markers of aortic dissection(AD)and evaluate their values in the diagnosis and prognosis.Methods Sixty cases of AD patients treated in our hospital from February 2014 to February 2017 were selected for the study(group AD),and one hundred patients with non-AD at the same time were selected as the control group.In both groups,the serum levels of TGF-β,CRP,UA,D-dimer and troponin I(cTNI)were detected,and compared differences of levels of these markers in different prognoses.Results For group AD patients,the CRP,D-dimer,TGF-β,UA and cTNI were 34.22±4.12ng/mL,14.50±2.01mg/mL,870.04±60.03 ng/mL,385.52±32.08ng/mL and 2.41±0.15 ng/mL,significantly higher than the control group(P<0.05);For the death group,the TGF-β,CRP,D-dimer and cTNI were 38.11±3.27 ng/mL,16.40±2.08 mg/L,902.12±40.04 ng/mL and 2.61±0.30ng/mL,significantly higher than the survival group(P<0.05);The levels of TGF-β,CRP,D-dimer,UA and cTNI all had some values in the diagnosis of AD.The area of ROC curve of TGF-βD-dimer was 0.901,with the cut-off value of 30.12ng/mL,the sensitivity and specificity of 80.40%and 84.44%;The levels of TGF-β,CRP,D-dimer had values in judging the prognosis of patients with AD.The ROC curve area of D-dimer judged death was 0.782,with the cut-off value of 890.62ng/mL,the sensitivity and specificity of 85.56%and 80.05%.Conclusion TGF-β,CRP,D-dimer and other serum markers havepromising clinical values in the diagnosis and prognosis of AD.TGF-βis more effective in the diagnosis of AD,while D-dimer is more effective in judging the prognosis.

关 键 词:转化生长因子 C反应蛋白 尿酸 D-二聚体 主动脉夹层 诊断 

分 类 号:R543.1[医药卫生—心血管疾病] R446.6[医药卫生—内科学]

 

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