喜炎平注射液治疗小儿细菌性下呼吸道感染的临床研究  

Clinical research of Xiyanping injection in the treatment of pediatric bacterial lower respiratory tract infection

作　　者：陈晓媛[1] 马金海[1] CHEN Xiaoyuan;MA Jinhai(Ningxia Medical University Hospital of Pediatrics,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院儿科,银川750004

出　　处：《中国中西医结合儿科学》2018年第6期479-481,共3页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：目的观察喜炎平注射液治疗小儿细菌性下呼吸道感染的临床疗效。方法选择2015年1月至2016年1月宁夏医科大学总医院儿科收治的下呼吸道感染(痰培养阳性)患儿212例为研究对象,随机分为观察组和对照组各106例。对照组应用抗生素、雾化吸入等常规治疗,观察组在对照组基础上给予静脉滴注喜炎平注射液,疗程7d。观察两组患儿临床疗效,退热时间、咳嗽缓解时间、肺部体征消失时间、住院时间,C反应蛋白、血沉、白细胞计数和肺功能(潮气呼气峰流速)的恢复情况。结果观察组临床总有效率为94.3%(100/106),显著高于对照组76.4%(81/106),差异有统计学意义(P<0.05)。治疗5d后观察组患儿痰培养阳性率为7.3%(15/106),显著低于对照组28.3%(30/106),差异有统计学意义(P<0.05)。观察组患儿退热时间、咳嗽缓解时间、肺部体征消失时间、住院时间均显著低于对照组,差异有统计学意义(P<0.05)。治疗后观察组C反应蛋白、血沉、白细胞计数均低于对照组,潮气呼气峰流速高于对照组,差异有统计学意义(P<0.05)。结论喜炎平注射液治疗小儿细菌性下呼吸道感染效果显著。Objective To observe the clinical effect of Xiyanping injection in the treatment of pediatric bacterial lower respiratory tract infection.Methods A total of212children treated for lower respiratory tract infection(positive sputum culture)in General Hospital of Ningxia Medical University from Jan.2015to Jan.2016were chosen as the research subjects,who were randomly divided into observation group and control group(106cases in each group).Conventional treatment with antibiotics and atomization inhalation was given to both groups,and observation group was also given venous dripping of Xiyanping injection.The treatment lasted for7days.The improvement in the following aspects were observed in the two groups:clinical effect,fever-relief time,cough-relief time,time for pulmonary signs to disappear,hospitalization time,C-reactive protein,erythrocyte sedimentation rate(ESR),white blood cell count and lung function(tidal expiratory peak velocity).Results The clinical total effective rate in observation group was94.3%(100/106),which was significantly higher than that in control group(76.4%,81/106)(P<0.05).After5days of treatment,the positive rate of sputum culture in observation group was7.3%(15/106),significantly lower than that in control group(28.3%,30/106)(P<0.05).The fever-relief time and cough-relief time,the time for pulmonary signs to disappear and the length of hospital stay were all significantly shorter in observation group than in control group(P<0.05).The C-reactive protein,erythrocyte sedimentation rate and WBC counts in observation group were lower than those in control group after treatment,while the tidal expiratory peak velocity was higher,the difference being statistically significantly(P<0.05).Conclusion Xiyanping injection has good effect in the treatment of bacterial lower respiratory tract infection in children.

关 键 词：下呼吸道感染 细菌性 喜炎平 儿童 

分 类 号：R725.6[医药卫生—儿科]