多磺酸粘多糖乳膏联合地奈德乳膏治疗婴儿湿疹的临床观察  

Clinical observation of Mucopolysaccharide polysulfate cream combined with Desonide cream in the treatment of infantile eczema

作　　者：王菲[1] 郭英军[2] WANG Fei;GUO Yingjun(Shengjing Hospital Affiliated to China Medical University, Shenyang 110000,China)

机构地区：[1]中国医科大学 [2]中国医科大学附属盛京医院皮肤科

出　　处：《中国中西医结合儿科学》2018年第6期531-533,共3页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：目的探讨多磺酸粘多糖乳膏联合地奈德乳膏治疗婴儿湿疹的疗效及安全性。方法 2017年9月至2018年3月中国医科大学附属盛京医院皮肤科门诊收治婴儿湿疹200例,随机分为观察组和对照组,各100例。观察组予地奈德乳膏联合多磺酸粘多糖乳膏外用;对照组单独外用地奈德乳膏;两组疗程均为2周。于治疗第1周、第2周和第4周分别记录皮疹情况及不良反应。结果治疗2周后观察组总有效率为88.0%(88/100),显著高于对照组,77.0%(77/100),差异有统计学意义(P<0.05)。4周后随访,观察组复发率16.0%(16/100),显著低于对照组48.0%(48/100),差异有统计学意义(P<0.05)。两组患儿治疗期间均未发现不良反应。结论多磺酸粘多糖乳膏联合地奈德乳膏治疗婴儿湿疹疗效好,复发率及不良反应少,相对安全,在临床值得推广。Objective To investigate the efficacy and safety of Mucopolysaccharide polysulfate cream combined with Desonide cream in the treatment of infantile eczema.Methods From September 2017 to March 2018,200 cases of infantile eczema were treated in the dermatology clinic of Shengjing Hospital Affiliated to China Medical University.They were randomly divided into a control group and an observation group,each with100cases.The observation group was treated with Desonide cream and Mucopolysaccharide polysulfate cream for external use;the control group was treated with topical Desonide cream alone.The rash and adverse reactions were recorded at the first week,the second week,and the fourth week of treatment.Results After two weeks of treatment,the total effective rate of the observation group was 88.0%(88/100),which was significantly higher than that of the control group,77.0%(77/100),the difference being statistically significant(P<0.05).After four weeks of treatment,the recurrence rate of the observation group was16.0%(16/100),which was significantly lower than that of the control group(48.0%,48/100),and the difference was statistically significant(P<0.05).No adverse reactions were found during the treatment in both groups of children.Conclusion Mucopolysaccharide polysulfate cream combined with Desonide cream is effective in treating infantile eczema,with lower recurrence rate and fewer adverse reactions,and is relatively safe.It is worthy of promotion in clinical practice.

关 键 词：湿疹 多磺酸粘多糖乳膏 地奈德乳膏 婴儿 

分 类 号：R75[医药卫生—皮肤病学与性病学]