盐酸氨酮戊酸散光动力疗法治疗尖锐湿疣的临床疗效分析  

Analysis of the clinical efficacy of aminoketovalic acid hydrochloride astigmatic photodynamic therapy in the treatment of condyloma acuminatum

作　　者：李小群[1] 胡立明 陈国菊[2] 郭惠娟[1] 温云鹏 朱斌[4] LI Xiaoqun;HU Liming;CHEN Guoju;GUO Huijuan;WEN Yunpeng;ZHU Bin(Department of Pharmacy,Bao′an District Maternal and Child Health Care Hospital,Shenzhen 518102,Guangdong,China;Department of Dermatology,Bao′an District Maternal and Child Health Care Hospital,Shenzhen 518102,Guangdong,China;Department of Dermatology,Bao′an District People′s Hospital,Shenzhen 518100,Guangdong,China;Department of Urology,Pingshan New District People′s Hospital of Shenzhen,Shenzhen 518000,Guangdong,China)

机构地区：[1]深圳市宝安区妇幼保健院药剂科,广东深圳518102 [2]深圳市宝安区妇幼保健院皮肤科,广东深圳518102 [3]深圳市宝安区人民医院皮肤科,广东深圳518100 [4]深圳市坪山新区人民医院泌尿外科,广东深圳518000

出　　处：《中国性科学》2018年第11期125-128,共4页Chinese Journal of Human Sexuality

基　　金：广东省医学科学技术研究基金项目(A2015572)

摘　　要：目的:分析盐酸氨酮戊酸散光动力疗法治疗尖锐湿疣的临床疗效。方法:选取2015年2月至2016年5月深圳市宝安区妇幼保健院接受治疗的88例尖锐湿疣患者为研究对象。根据随机数字表法将其分为观察组和对照组,每组44例患者。观察组患者给予盐酸氨酮戊酸散光动力疗法治疗,对照组患者给予常规治疗,比较两组患者治疗效果。结果:观察组患者治愈人数占比和治疗总有效率分别为61. 4%(27/44)、90. 9%(40/44),均显著高于对照组患者的38. 6%(17/44)、63. 6%(28/44);观察组患者尿道口与非尿道口的复发率均显著低于对照组患者;治疗后观察组患者的IL-2水平显著高于对照组患者,而IL-10水平显著低于对照组患者;观察组患者疼痛、溃疡、瘢痕、尿道感染和红肿发生率均显著低于对照组患者,差异均有统计学意义(均P <0. 05)。结论:盐酸氨酮戊酸散光动力疗法治疗尖锐湿疣患者的临床疗效显著,可以有效降低复发率和不良反应发生率,具有较好的安全性。其作用机制可能与提高IL-2水平、降低IL-10水平有关。Objective:To study the clinical efficacy of aminoketovalic acid hydrochloride astigmatic photodynamic therapy for the treatment of condyloma acuminatum(CA).Methods:88 patients with CA in Bao′an District People′s Hospital from February 2015 to May 2016 were selected and divided into observation group(n=44)and control group(n=44)according to random number table method.The control group received conventional therapy,while patients in the observation group received aminoketovalic acid hydrochloride astigmatic photodynamic therapy.The therapeutic effect was compared between the two groups.Results:The ratio of cured number and total effective rate in the observation group was 61.4%(27/44)and 90.9%(40/44)respectively,significantly higher than that of the control group which was 38.6%(17/44)and 63.6%(28/44)respectively.The recurrence rate in the observation group was significantly lower than that of the control group.After treatment,the IL-2 level and IL-10 level in the observation group was significantly higher and lower than that in the control group respectively.The incidences of pain,ulcers,scarring,urinary tract infection and inflammation in the observation group were significantly lower than those of the control group,with statistically significant differences(all P<0.05).Conclusions:Aminoketovalic acid hydrochloride astigmatic photodynamic therapy is effective in the treatment of patients with CA,which can effectively reduce the recurrence rate and incidence of adverse reactions with high safety.The mechanism may be related to increased level of IL-2 and reduced level of IL-10.

关 键 词：盐酸氨酮戊酸 散光动力疗法 尖锐湿疣 疗效 安全性 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]