三酰甘油/高密度脂蛋白-胆固醇比值与血压正常人群动脉硬化进展的关系  

Relation between triglyceride and high density lipoprotein cholesterol ratios with progression of arterial stiffness in normotensive subjects

作　　者：姚涛 田柏淋 胡丹 李刚[3] 刘璋 YAO Tao;TIAN Bolin;HU Dan;LI Gang;LIU Zhang(Department of Neurology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]湖北省人民医院神经内科Ⅰ科,武汉430060 [2]大悟县中医院,湖北孝感432800 [3]湖北省中医院急救部,武汉430061

出　　处：《实用医学杂志》2018年第24期4072-4075,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81401051)

摘　　要：目的探讨血浆三酰甘油/高密度脂蛋白-胆固醇比值(TG/HDL-C)预测血压正常人群动脉硬化进展的价值。方法对816名研究对象进行5年的随访,记录入组时性别、年龄、身高、体质量及血脂参数等基线资料,使用颈-股动脉脉搏波传导速度(cfPWV)检查评估入组时和5年后随访时动脉硬化程度。结果高血浆TG/HDL-C比值组人群随访时cfPWV、cfPWV变化值(△cfPWV)、年平均cfPWV变化值和异常cfPWV显著增加(P <0.001)。调整变量后多元回归分析,结果显示血浆TG/HDL-C比值可以独立预测动脉硬化进展(P <0.001)。调整性别、年龄、吸烟、体育锻炼、体质指数、收缩压、平均动脉压、心率、基线cfPWV、肌酐以及空腹血糖影响后,Cox回归模型分析结果表明血浆TG/HDL-C比值能够独立预测5年之后cfPWV异常(HR=1.121,95%CI:1.008～1.248,P=0.036)。结论血压正常人群中血浆TG/HDL-C比值能独立预测动脉硬化的进展。高TG/HDL-C比值者具有更高的动脉硬化风险。Objective This study was conducted to prospectively assess the association between the ratio of triglyceride to HDL-C(TG/HDL-C)with aortic stiffness progression in normotensive subjects.Methods We followed up 816 normotensive participants for nearly five years. Date of gender,age,body height,weight,plasma lipid parameters and other data was collected at baseline. Carotid-femoral pulse wave velocity(cfPWV)was used to measure aortic stiffness at baseline and the end of follow-up.Results In highest TG/HDL-C ratio group,follow-upcfPWV,△cfPWV,annual△cfPWVand abnormal cfPWVweresignificantlyincreased at the end of follow-up(P <0.001). After adjustment for covariates,triglyceride to HDL-C ratio is significantly related to the progression of cfPWV(P < 0.001). After adjusted the covariates including gender,age,exercise,smoking,drinking,BMI,SBP,MAP,FBG,UA,baseline cfPWV,TG/HDL-C ratio were able to independently predict abnormal cfPWV after 5 years(HR = 1.121,95%CI:1.008 ~ 1.248,P =0.036).Conclusion The level of TG/HDL-C ratio can independently predict arterial stiffness progression in normotensive subjects. High level of TG/HDL-C ratio were associated with a higher risk of arterial stiffness.

关 键 词：动脉硬化 血脂 三酰甘油 高密度脂蛋白-胆固醇 颈-股动脉脉搏波传导速度 

分 类 号：R543.5[医药卫生—心血管疾病]