早期复发性流产患者血浆维生素D水平及其与D-二聚体的相关性研究  

The Correlation Between Plasma Vitamin D and D-dimer in Women with Recurrent Spontaneous Abortion(RSA)

作　　者：黄仲英[1] 杨丽[1] 马黔红[1] 沈琼燕 HUANG Zhong-ying;YANG Li;MA Qian-hong;SHEN Qiong-yan(Department of Obstetrics and Gynecology,West China Second Hospital,Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children,Ministry of Education,Chengdu 610041,China)

机构地区：[1]四川大学大学华西第二医院/出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中国食物与营养》2018年第12期84-86,共3页Food and Nutrition in China

基　　金：国家自然科学基金"microRNA及靶向HLA-E的siRNA介导孕激素对母胎界面的免疫调控及在URSA发生机制中的作用"(项目编号:81200453);成都市科技局科研项目"原因不明复发性流产母胎界面的线粒体蛋白质组学研究"(项目编号:2015-HM01-00494)

摘　　要：目的:检测复发性流产(RSA)患者血清维生素D (维生素D)水平并探讨其与D-二聚体(D-DI)表达的相关性。方法:回顾性分析179例(包括对照组49例、RSA组65例及不孕组65例)患者血浆总维生素D水平和D-DI水平。结果:RSA组和不孕组患者血浆维生素D水平低于对照组,差异有统计学意义(P <0. 05),但RSA组和不孕组两组患者间维生素D水平无显著性差异。RSA组血浆D-DI水平显著高于不孕组及对照组(P <0. 05);RSA组维生素D水平与D-DI呈负相关,但无统计学意义。结论:RSA患者及不孕患者中维生素D不足的比例较高;RSA组维生素D水平不足及其与之相关的血浆D-DI增高倾向,可能参与早期复发性流产的发生。Objective To detect the concentration of plasma vitamin D and explore the correlation between plasma vitamin D and D-dimer in women with spontaneous abortion(RSA).Method The plasma levels of vitamin D and D-dimer in 179 women(including 49 controls,65 RSA women and 65 infertile women)were retrospectively analyzed.Result Vitamin D levels in RSA and infertile group were significantly lower than that in the control group(P<0.05),while there was no difference between the RSA and infertile group.The D-dimer levels in RSA group was significantly higher than those in infertile group or the control group.The plasma vitamin D levels were negatively correlated with D-dimer in RSA group,while without statistic significance.Conclusion There was a high proportion of women with vitamin D insufficiency in RSA and infertile group.The insufficiency of vitamin D and the increase of D-Dimer may play a role in the pathogenesis of RSA.

关 键 词：维生素D D-二聚体 复发性流产 

分 类 号：R714.21[医药卫生—妇产科学]