生长激素在卵巢储备功能低下患者IVF-ET中的应用  

Application of growth hormone in IVF-ET cycle for patients with diminished ovarian reserve

作　　者：王雪梅[1] 刘迎春[1] 黄静 胡玉琴 宋小敏 刘颖[1] 姜宏[1] WANG Xue-mei;LIU Ying-chun;HUANG Jing;HU Yu-qin;SONG Xiao-min;LIU Ying;JIANG Hong(Reproductive Medicine Centre,105 th Hospital of People’s Liberation Army,Hefei 230031)

机构地区：[1]中国人民解放军第105医院生殖医学中心,合肥230031

出　　处：《生殖医学杂志》2019年第1期41-44,共4页Journal of Reproductive Medicine

摘　　要：目的探讨重组人生长激素(r-hGH)在卵巢储备功能低下(DOR)患者IVF-ET中的应用价值。方法回顾性分析2011年3月至2017年4月在我院生殖中心行体外受精-胚胎移植(IVF-ET)173例DOR患者的临床资料,将促排卵过程中加用r-hGH者纳为GH组(71例),未添加GH者纳为对照组(102例),比较两组的IVF-ET结局。结果两组间患者一般情况、Gn用量和天数、HCG日子宫内膜厚度和激素水平、获卵数、成熟卵数、优质胚胎数、冷冻胚胎数、受精率、卵裂率及早期流产率均无显著性差异(P>0.05);GH组的临床妊娠率及胚胎种植率均显著高于对照组,分别为(45.1%vs.30.4%)和(26.8%vs.16.9%),差异有显著性(P<0.05)。结论促排卵过程中添加r-hGH可以提高DOR患者的胚胎种植率及临床妊娠率,改善其IVF-ET结局。Objective:To investigate the effect of recombinant human growth hormone(r-hGH)on the IVF-ET outcomes of the patients with diminished ovarian reserve(DOR).Methods:The clinical data of the 173 DOR patients received IVF-ET in our center from March 2011 to April 2017 were analyzed retrospectively.All enrolled patients were assigned into GH group(n=71)and control group(n=102)according to whether addition of r-hGH or not in the process of controlled ovarian stimulation(COS)and the clinical outcomes of IVF-ET were compared between the two groups.Results:There were no significant differences in the patients’characteristics between the two groups.The duration and dosage of gonadotropin(Gn),the hormone level,endometrial thickness on the HCG day,the numbers of oocytes retrieved and mature oocytes,the rates of fertilization and cleavage,the numbers of high-quality embryos and frozen embryos,as well as early abortion rate were not significantly different between two groups(P>0.05).However,the clinical pregnancy rate(45.1%vs.30.4%)and implantation rate(26.8%vs.16.9%)in GH group were significantly higher than control group(P<0.05).Conclusions:Addition of r-hGH in COS can improve the outcome of IVF-ET for the patients with DOR.

关 键 词：生长激素 体外受精-胚胎移植 卵巢储备功能低下 临床结局 

分 类 号：R715.2[医药卫生—妇产科学]