温经通络法防治奥沙利铂致外周神经毒性的临床研究  

Clinical Study of Wenjing Tongluo Therapy on Preventing and Treating Oxaliplatin-Induced Peripheral Neurotoxicity

作　　者：刘青[1] 贡涛 汤秀红[1] LIU Qing;GONG Tao;TANG Xiuhong(Nanjing Hospital of TCM, Nanjing 210001, China)

机构地区：[1]南京市中医院,江苏南京210001

出　　处：《中医药信息》2019年第1期37-40,共4页Information on Traditional Chinese Medicine

摘　　要：目的:观察温经通络法防治奥沙利铂致外周神经毒性的临床疗效。方法:选取符合纳入标准的63例患者,采用随机对照的方法分为治疗组32例和对照组31例,分别在治疗前及治疗后3个月观察两组患者外周神经毒性发生的程度、临床疗效及NF-κB和TNF-α水平。结果:61例患者完成随访,2例患者因皮肤反应退出观察。治疗前两组患者外周神经毒性发生情况无显著性差异(P> 0. 05);治疗后对照组患者外周神经毒性发生的程度及NF-κB和TNF-α水平显著高于治疗组(P <0. 05),差异有统计学意义。治疗组患者的有效率为93. 3%(28/30),高于对照组74. 2%(23/31)(P <0. 05)。结论:运用温经通络法治疗能改善奥沙利铂致外周神经毒性反应,提高患者的治疗耐受及生存质量。Objective: To observe the clinical efficacy of Wenjing Tongluo(warming meridians to promote smooth flow of qi ) therapy preventing and treating Oxaliplatin-induced peripheral neurotoxicity. Methods: 63 tumor patients ever treated with Oxaliplatin were randomly divided into the treatment group(n=32) and the control group(n=31). The degree of peripheral neurotoxicity, efficacy of Chinese medication, as well as the levels of NF-κB and TNF-α were observed and compared before the treatment and three months after the treatment in the two groups. Results: 61 patients completed the observation, and 2 patients withdrew from the study due to skin reaction. There was no statistical difference between the two groups in terms of the incidence of peripheral neurotoxicity( P >0.05). After the treatment, the degree of peripheral neurotoxicity, and the levels of NF-κB and TNF-α were significantly higher in the control group than those in the treatment group( P<0.05). The effective rate was 93.3%(28/30) in the treatment group, which was significantly higher than 74.2%(23/31) in the control group( P<0.05). Conclusion: Wenjing Tongluo therapy can improve Oxaliplatin-induced peripheral neurotoxicity, it can increase the treatment tolerance and life quality of the patients.

关 键 词：温经通络 奥沙利铂 外周神经毒性 

分 类 号：R285.6[医药卫生—中药学]