糖通饮治疗早期糖尿病肾病临床研究  

Clinical Study of Tangtong Yin Treating Early DN

作　　者：潘艳伶[1,2,3] 侯胜开 高楠楠 屈璐[1] 伍鋆[2] 毕瑩 PAN Yanling;HOU Shengkai;GAO Nannan;QU Lu;WU Yun;BI Ying(Guizhou Medical University, Guizhou 550004, China;Affiliated Hospital of Guizhou Medical University,Guizhou 550001, China;Guizhou Provincial Key Laboratory of Pathogenesis & Drug Research on Common Chronic Diseases, Guizhou Medical University, Guizhou 550004, China)

机构地区：[1]贵州医科大学,贵州贵阳550004 [2]贵州医科大学附属医院,贵州贵阳550001 [3]贵州省常见慢性疾病发病机制及药物研究重点实验室,贵州贵阳550004

出　　处：《中医药信息》2019年第1期91-94,共4页Information on Traditional Chinese Medicine

基　　金：贵阳市人民政府-贵州医科大学联合基金社会发展攻关项目(No.筑科合同20161001号)

摘　　要：目的:观察名老中医经验方糖通饮治疗早期糖尿病肾病的临床疗效,并初步探讨其可能的作用途径。方法:将符合纳入标准的早期糖尿病肾病患者60例随机分为治疗组(30例)和对照组(30例)。对照组口服安博维,治疗组口服糖通饮,分别治疗12周后,比较两组治疗前后24 h尿蛋白定量、尿微量白蛋白排泄率(UAER)、血清转化生长因子-β1(TGF-β1)、肾功、糖化血红蛋白、血糖和血脂的变化。结果:治疗组治疗后24 h尿蛋白定量、尿微量白蛋白排泄率、血清转化生长因子-β1、空腹血糖(FBG)、糖化血红蛋白(HbAlc)、甘油三酯(TG)、总胆固醇(TC)均明显下降(P <0. 05或P <0. 01),与对照组治疗后比较差异具有显著性(P <0. 05)。结论:糖通饮能有效降低早期糖尿病肾病患者UAER,减轻蛋白尿,治疗早期糖尿病肾病疗效较好,可在一定程度上控制糖尿病肾病的发展,其作用途径可能和有效降低TGF-β1含量、改善血糖、血脂有关。Objective:To observe the clinical effect of Tangtong Yin in the treatment of early diabetic nephropathy(DN) and explore the possible mechanism. Methods: 60 early DN were randomly divided into the treatment group(n=30) and the control group(n=30). The control group was treated with Irbesartan, and the treatment group was treated with Tangtong Yin. After 12 weeks of treatment, 24 h urinary protein quantification, urinary albumin excretion rate(UAER), changes of serum transforming growth factor-β1(TGF-β1), renal function, glycosylated hemoglobin, blood glucose and blood lipids were compared between the two groups. Results: 24 h urinary protein quantity, UAER and TGF-β1, glycosylated hemoglobin(Hbalc), fasting blood glucose(FBG), triglyceride(TG), and total cholesterol(TC) were significantly decreased in the treatment group( P<0.05, P<0.01);the differences were significant when compared to those in the control group compared with the control group( P<0.05). Conclusion: Tangtong Yin can effectively reduce UAER and proteinuria of early DN patients. It has a good effect on early DN and it can control the development of DN to a certain extent. The action path of Tangtong Yin may be related to reducing the content of TGF-β1 in patients and improving blood sugar and blood lipids.

关 键 词：糖通饮 早期糖尿病肾病 名老中医经验方 转化生长因子-Β1 血糖 血脂 UAER 

分 类 号：R587.2[医药卫生—内分泌]