β_2-微球蛋白和白细胞介素-6在不同分期多发性骨髓瘤患者中的表达  

Expression of β_2-microglobulin and interleukin-6 in patients with multiple myeloma at different stages

作　　者：关建民[1] 付彬[2] Guan Jianmin;Fu Bin(Heze Medical College,Heze 274000,Shandong;Heze Municipal Hospital,Heze 274000,Shandong)

机构地区：[1]菏泽医学专科学校 [2]菏泽市立医院,山东菏泽274000

出　　处：《菏泽医学专科学校学报》2018年第4期7-9,共3页Journal of Heze Medical College

基　　金：山东省医药卫生科技发生计划项目;项目编号:2014WS0400

摘　　要：目的探讨β_2-微球蛋白和白细胞介素-6在多发性骨髓瘤不同分期患者中的表达情况及意义。方法选择多发性骨髓瘤患者72例作为观察组,另选70例健康志愿者为对照组。采用ELISA方法检测不同分期多发性骨髓瘤患者及正常对照组血浆中β_2-微球蛋白和白细胞介素-6水平。结果观察组I期、II期和III期的β_2-微球蛋白和白细胞介素-6水平高于对照组,两组比较P<0.05;观察组III期的β_2-微球蛋白和白细胞介素-6测定水平均显著高于I期、II期,差异均具有统计学意义(P<0.05)。结论多发性骨髓瘤患者随着病情进展,的表达水平增高,提示β_2-微球蛋白和白细胞介素-6可能与多发性骨髓瘤疾病进展有关,提示了不良预后,可以作为治疗效果和预后判断的重要指标。Objective To explore the expression of β2-microglobulin and interleukin-6 in patients with multiple myeloma at different stages. Methods The levels of β2-microglobulin and interleukin-6 in patients with multiple myeloma of different stages and in normal people were measured by ELISA. Results The levels of interleukin-6 in patients with multiple myeloma at stage III were significantly higher than those in patients at stage I and II (P<0.05) and the levels of β2- microglobulin and interleukin-6 in patients with multiple myeloma were significantly higher than those in the control group (P<0.05). Conclusion The expression of β2-microglobulin and interleukin-6 increased with the progression of multiple myeloma, which suggested that β2-microglobulin and interleukin-6 may be related to the progression of multiple myeloma, and they can be used as important indicators of therapeutic effect and prognosis.

关 键 词：Β2-微球蛋白 白细胞介素-6 多发性骨髓瘤 

分 类 号：R551.3[医药卫生—血液循环系统疾病]