聚多巴胺包覆的金纳米棒用于大鼠下颌下腺造影成像  

Polydopamine-coated Gold Nanorods for Rat Submandibular Gland Radiography

作　　者：宋子琦 公柏娟[1] 王璐[1] 冯婧[1] 王博 闫弘静 李志民[1] 孙宏晨[1] SONG Ziqi;GONG Baijuan;WANG Lu;FENG Jing;WANG Bo;YAN Hongjing;LI Zhimin;SUN Hongchen(School and Hospital of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院,长春130021

出　　处：《高等学校化学学报》2019年第1期166-172,共7页Chemical Journal of Chinese Universities

基　　金：吉林省科技发展计划项目(批准号:20170414047GH);吉林大学高层次科技创新团队建设项目(批准号:2017TD-11)资助~~

摘　　要：用生物相容性好且毒性低的聚多巴胺对金纳米棒进行表面包覆,利用其造影增强的功能,将聚多巴胺包覆的金纳米棒应用于大鼠下颌下腺导管,实现了下颌下腺造影成像.We demonstrate the application of polydopamine-coated gold nanorods in the CT imaging of rat submandibular gland.Biocompatible polydopamine was coated on the surface of gold nanorods to lower the toxicity.CT value rises with the increase of the concentration of polydopamine-coated gold nanorods in vitro,which indicates the high sensitivity to X-ray.The polydopamine-coated gold nanorods are further applied to rat submandibular gland in vivo and radiographs are obtained.H&E staining of heart,liver,spleen,lungand kidney show no obvious inflammation for the rats.

关 键 词：金纳米棒 计算机体层扫描 下颌下腺 造影成像 

分 类 号：O631[理学—高分子化学]